Now showing items 31-40 of 49
A possible role in the regulation of primary amination for a complex of glutamine: [alpha]-Ketoglutarate amidotransferase and glutamate dehydrogenase in
(Elsevier, 1972-07-11)
Both glutamine: [alpha]-ketoglutarate amidotransferase and glutamate dehydrogenase activities are obtained from grown in minimal medium containing glucose and ammonia. These activities are not additive, suggesting an ...
Equivalence between S-systems and Volterra systems
(Elsevier, 1986-03)
S-systems and Volterra systems have been developed independently of each other in different branches of biology. We show that these systems are mathematically equivalent.
RNA splicing: Advantages of parallel processing
(Elsevier, 1982-10-21)
Parallel and sequential modes of RNA processing are systematically compared by an analysis of the relevant kinetic reaction schemes. The parallel mode is shown to be superior in the sense that it allows molecules to be ...
Accuracy of proofreading with zero energy cost
(Elsevier, 1981-11-07)
Accuracy of biological discrimination at the molecular level is known in some systems to involve kinetic proofreading mechanisms. Hopfield and Ninio were the first to propose simple specific kinetic mechanisms for such ...
Modeling immunotherapy of the tumor – immune interaction
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-09)
A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-2) may boost the immune system to fight tumors. CD4 + T cells, the cells that orchestrate the immune response, use these cytokines ...
Escherichia coli gene transfer to unrelated bacteria by a histidine operon -- RP1 drug resistance plasmid complex
(Elsevier, 1974-07-10)
SummaryGenetic and physical evidence indicates that the Pseudomonas aeruginosa drug resistance factor, RP1, may promote the transfer of Escherichia coli histidine genes. The RP1 mobilized histidine genes are functionally ...
Plasmid-determined tetracycline resistance in Streptococcus faecalis: Tandemly repeated resistance determinants in amplified forms of pAM[alpha]1 DNA
(Elsevier, 1976-04-15)
We recently reported that the six-megadalton plasmid pAM[alpha]1 (one of two plasmids in Streptococcus faecalis strain DS-5C1) undergoes a gene amplification as a result of extended growth (many generations) of cells in ...
Proofreading systems of multiple stages for improved accuracy of biological discrimination
(Elsevier, 1980-07-07)
The phenomenal accuracy of biological discrimination is due in many cases to specific proofreading mechanisms. We have previously developed a macroscopic theory of such mechanisms and applied it to the case of single-stage ...
Effects of Rifampicin resistant rpoB mutations on antitermination and interaction with nusA in Escherichia coli
(Elsevier, 1988-11-20)
Rifampicin resistant (Rifr mutations map in the rpoB gene encoding the [beta] subunit of Escherichia coli RNA polymerase. We have used our collection of 17 sequenced Rifr mutations to investigate the involvement of E. coli ...
Biochemical systems theory and metabolic control theory: 1. fundamental similarities and differences
(Elsevier, 1987-10)
Biochemical Systems Theory (BST) was developed in the late 1960s to explicate the integrated behavior of intact biochemical systems--specific dynamic behavior as well as general principles of design--in relation to the ...