Now showing items 1-10 of 102
Differentiate to thrive: lessons from the Legionella pneumophila life cycle
(Blackwell Science Ltd, 2004-07)
When confronted by disparate environments, microbes routinely alter their physiology to tolerate or exploit local conditions. But some circumstances require more drastic remodelling of the bacterial cell, as sporulation ...
Aspiration Pneumonia: Dental and Oral Risk Factors in an Older Veteran Population
(Blackwell Science Inc, 2001-05)
To investigate the importance of medical and dental factors in aspiration pneumonia in an older veteran population. DESIGN: Prospective enrollment of subjects with retrospective analysis of data. SETTING: Department of ...
On the use of metaphor to understand, explain, or rationalize redundant genes in yeast
(Blackwell Publishing Ltd, 2008-05)
The proposal that yeast, and cells in general, contains redundant genes that enable cells to survive mutational change has been supported by experiments and a strong metaphor. The redundant gene proposal is analyzed, and ...
The equilibria that allow bacterial persistence in human hosts
(Nature Publishing Group, 2007-10-18)
We propose that microbes that have developed persistent relationships with human hosts have evolved cross-signalling mechanisms that permit homeostasis that conforms to Nash equilibria and, more specifically, to evolutionarily ...
The Effects of Different HIV Type 1 Strains on Human Thymic Function
(Mary Ann Liebert, Inc., publishers, 2002-11-20)
Studies of HIV-1-infected humans indicate that the thymus can be infected by HIV-1. In some of these patients, there is a significant CD4+ T cell decline and a faster disease progression. This phenomenon is more evident ...
The high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection
(Blackwell Publishing Ltd, 2008-03)
Proteus mirabilis is a ubiquitous bacterium associated with complicated urinary tract infection (UTI). Mutagenesis studies of the wild-type strain HI4320 in the CBA mouse model of ascending UTIs have identified attenuated ...
A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila
(Blackwell Science Ltd, 2002-04)
Pathogenic Legionella pneumophila evolved as a parasite of aquatic amoebae. To persist in the environment, the microbe must be proficient at both replication and transmission. In laboratory cultures, as nutrients become ...
Repression of motility during fimbrial expression: identification of 14 mrpJ gene paralogues in Proteus mirabilis
(Blackwell Publishing Ltd, 2008-07)
Proteus mirabilis alternates between motile and adherent forms. MrpJ, a transcriptional regulator previously reported to repress motility, is encoded at the 3′ end of the mrp fimbrial operon in P. mirabilis . Sequencing ...
Legionella pneumophila couples fatty acid flux to microbial differentiation and virulence
(Blackwell Publishing Ltd, 2009-03)
During its life cycle, Legionella pneumophila alternates between at least two phenotypes: a resilient, infectious form equipped for transmission and a replicative cell type that grows in amoebae and macrophages. Considering ...
Checkpoints and restriction points in bacteria and eukaryotic cells
(Wiley Subscription Services, Inc., A Wiley Company, 2006-10)
Bacterial checkpoints, analogous to those proposed to exist in eukaryotic cells, offer insights into the definition of a checkpoint. Examination of bacterial “checkpoint” or arrest phenomena illustrate problems with a ...