Now showing items 1-10 of 89
Targeted disruption of the PD78 gene ( traF ) reduces pheromone-inducible conjugal transfer of the bacteriocin plasmid pPD1 in Enterococcus faecalis
(Blackwell Publishing Ltd, 1995-05)
Bacterial sex pheromone, cPD1, induces sexual aggregation of Enterococcus faecalis harboring the bacteriocin plasmid, pPD1, and enables pPD1 to transfer at high frequency in a liquid culture. PD78 is a cPD1-inducible cell ...
Differentiate to thrive: lessons from the Legionella pneumophila life cycle
(Blackwell Science Ltd, 2004-07)
When confronted by disparate environments, microbes routinely alter their physiology to tolerate or exploit local conditions. But some circumstances require more drastic remodelling of the bacterial cell, as sporulation ...
On the use of metaphor to understand, explain, or rationalize redundant genes in yeast
(Blackwell Publishing Ltd, 2008-05)
The proposal that yeast, and cells in general, contains redundant genes that enable cells to survive mutational change has been supported by experiments and a strong metaphor. The redundant gene proposal is analyzed, and ...
HIV's evasion of the cellular immune response
(Blackwell Publishing Ltd, 1999-04)
Despite a strong cytotoxic T-lymphocyte (CTL) response directed against viral antigens, untreated individuals infected with the human immunodeficiency virus (HIV-1) develop AIDS, We have found that primary T cells infected ...
The high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection
(Blackwell Publishing Ltd, 2008-03)
Proteus mirabilis is a ubiquitous bacterium associated with complicated urinary tract infection (UTI). Mutagenesis studies of the wild-type strain HI4320 in the CBA mouse model of ascending UTIs have identified attenuated ...
A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila
(Blackwell Science Ltd, 2002-04)
Pathogenic Legionella pneumophila evolved as a parasite of aquatic amoebae. To persist in the environment, the microbe must be proficient at both replication and transmission. In laboratory cultures, as nutrients become ...
Repression of motility during fimbrial expression: identification of 14 mrpJ gene paralogues in Proteus mirabilis
(Blackwell Publishing Ltd, 2008-07)
Proteus mirabilis alternates between motile and adherent forms. MrpJ, a transcriptional regulator previously reported to repress motility, is encoded at the 3′ end of the mrp fimbrial operon in P. mirabilis . Sequencing ...
Legionella pneumophila couples fatty acid flux to microbial differentiation and virulence
(Blackwell Publishing Ltd, 2009-03)
During its life cycle, Legionella pneumophila alternates between at least two phenotypes: a resilient, infectious form equipped for transmission and a replicative cell type that grows in amoebae and macrophages. Considering ...
Analysis of ToxR-dependent transcription activation of ompU , the gene encoding a major envelope protein in Vibrio cholerae
(Blackwell Science Ltd, UK, 1998-07)
Transcriptional control of toxT , a regulatory gene in the ToxR regulon of Vibrio cholerae
(Blackwell Publishing Ltd, 1994-10)
Co-ordinate expression of many virulence genes in Vibrio cholerae is under the control of the ToxR and ToxT proteins. These proteins function in a regulatory cascade in which ToxR is required to activate toxT , and ToxT ...