Now showing items 11-20 of 20
ω- 123 I-Hexadecanoic acid metabolic probe of cardiomypathy
(Springer-Verlag, 1985-03)
The utility of ω- 123 I-hexadecanoic acid myocardial scintigraphy as a metabolic probe of cardiomyopathies was investigated. Sixteen patients with a variety of cardiomyopathies and myopathies that involve cardiac muscle ...
Autoradiographic quantification of muscarinic cholinergic synaptic markers in bat, shrew, and rat brain
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-05)
We employed radioligand binding autoradiography to determine the distributions of pre- and postsynaptic cholinergic radioligand binding sites in the brains of two species of bat, one species of shrew, and the rat. High ...
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders
(Springer-Verlag, 2001-10)
Rationale: There exists a wide range of animal models and measures designed to assess anxiety or fearfulness. However, the relationship between these models and clinical anxiety symptoms and syndromes is unclear. The ...
Getting to the crux of the matter: IL-23 and Th17 cell accumulation in the CNS
(WILEY-VCH Verlag, 2009-07)
IL-23 plays a critical role in EAE induced by the active immunization of C57BL/6 mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein (MOG 35–55 ). It was initially assumed that the pathogenic effects ...
The importance of age effects on performance in the assessment of clinical trials
(Elsevier, 1973-11)
Forty young adult normal subjects, 10 Parkinson's disease patients and their 10 matched normal subjects, and 10 multiple sclerosis patients and their 10 matched normal subjects were evaluated in the Quantitative Examination ...
The retina as a biochemical model of central nervous system regeneration
(Elsevier, 1980)
The visual system of primitive vertebrates has long served as a useful model for the resynthesis of damaged neurons. The prior optic nerve crush imparts a marked tendency on the part of cultured retinal explants to extend ...
Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs
(Kluwer Academic Publishers; Springer Science+Business Media, 2004-11)
Objectives : CCI-779 is an ester of the immunosuppressive agent sirolimus (rapamycin) that causes cell-cycle arrest at G1 via inhibition of key signaling pathways resulting in inhibition of RNA translation. Antitumor ...
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-08)
Purpose : Loss of PTEN, which is common in glioblastoma multiforme (GBM), results in activation of the mammalian target of rapapmycin (mTOR), thereby increasing mRNA translation of a number of key proteins required for ...
A qualitative and quantitative evaluation of amantadine in the treatment of Parkinson's disease
(Elsevier, 1972-03)
A double-blind crossover trial of amantadine vs. placebo was carried out involving 42 patients with Parkinson's disease: 64 per cent of the patients on amantadine experienced subjective improvement compared to 21 per cent ...
Quantitative in vivo receptor binding IV: Detection of muscarinic receptor down-regulation by equilibrium and by tracer kinetic methods
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1991-09)
Newly-developed methods for estimation of in vivo binding to neurotransmitter receptors should enable the detection and quantification of physiologic or pathologic changes in receptor numbers. In the present study, both ...