Now showing items 21-30 of 86
Axotomy increases CNTF receptor mRNA in rat spinal cord
(Elsevier, 1993-04-30)
In order to study the role of ciliary neurotrophic factor (CNTF) and its receptor (CNTF-R) in the response of spinal cord neurons to axotomy, we measured the levels of CNTF mRNA in nerve and CNTF-R mRNA in spinal cord ...
Unilateral striatal lesions in the cat disrupt well-learned motor plans in a GO/NO-GO reaching task
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1997-03)
We examined the changes in learned and spontaneous motor behavior after a unilateral excitotoxin lesion of the neostriatum. Cats were trained to perform a sensory-cued GO/NO-GO reaching task. Success rate, reaction time, ...
Distribution of GABAA and GABAB binding sites in the cochlear nucleus of the guinea pig
(Elsevier, 1994-03-14)
We compared the distribution of GABAA and GABAB binding sites in the cochlear nucleus using quantitative receptor autoradiography with [3H]GABA. To visualize GABAA binding sites, GABAB binding sites were blocked with ...
Changes in intra-axonal calcium distribution following nerve crush
(Wiley Subscription Services, Inc., A Wiley Company, 1986-09)
We used the oxalate-pyroantimonate method to demonstrate the ultrastructural distribution of calcium within rat sciatic nerve 4 h after a crush injury. In normal nerve there are discrete gradients of axoplasmic calcium ...
Primate basal ganglia activity in a precued reaching task: preparation for movement
(Springer-Verlag, 1993-07)
Single cell activity was recorded from the primate putamen, caudate nucleus, and globus pallidus during a precued reaching movement task. Two monkeys were trained to touch one of several target knobs mounted in front of ...
Mannose 6-phosphate potentiates insulin-like growth factor II effects in cultured human neuroblastoma cells
(Elsevier, 1991-10-18)
Insulin-like growth factor II (IGF-II) and mannose 6-phosphate (man-6-P) bind to distinct sites on the same receptor4,16,20. In the present study, we examined the effects of man-6-P on the growth promoting effects of IGF-II ...
Localization of striatal excitatory amino acid binding site subtypes to striatonigral projection neurons
(Elsevier, 1992-10-23)
Quantitative autoradiography was used to examine the cellular localization of excitatory amino acid binding sites in the striatum following selective lesion of striatonigral projection neurons. Degeneration of striatonigral ...
Regulation of insulin-like growth factor binding protein synthesis and secretion in human retinal pigment epithelial cells
(Wiley Subscription Services, Inc., A Wiley Company, 1994-01)
Cultured human retinal pigment epithelial cells (RPE) secrete insulin-like growth factor binding proteins (IGFBPs), a family of polypeptides which modulate the actions of the insulin-like growth factors. RPE cells secrete ...
Effects of excitotoxic striatal lesions on single unit activity in globus pallidus and entopeduncular nucleus of the cat
(Elsevier, 1989-11-06)
Striatal projections to the globus pallidus and entopeduncular nucleus are thought to be GABAergic and inhibitory. Thus, striatal lesions might be expected to increase the spontaneous discharge rate of neurons in these ...
PKC Activity and PKC-[alpha] mRNA Content Are Reduced in Serum-Deprived Human Neuroblastoma Cells without Concomitant Induction of Differentiation
(Elsevier, 1993-08)
Protein kinase C (PKC) is a serine/threonine kinase which is thought to play an important role in cellular proliferation and differentiation. PKC activity is stimulated physiologically by diacylglycerol and experimentally ...