Now showing items 31-40 of 86
Enhancing high-speed digitization of single-unit neuronal activity on a microcomputer using a hybrid software-hardware technique
(Elsevier, 1989-06)
A new data acquisition technique allows a microcomputer simultaneously to digitize spikes at high rates, analyze spike waveforms for computer-based spike separation and manage other control tasks. The technique has two key ...
Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells
(John Wiley & Sons, Inc., 1999-12)
Both neurons and glia succumb to programmed cell death (PCD) when deprived of growth factors at critical periods in development or following injury. Insulin-like growth factor-I (IGF-I) prevents apoptosis in neurons in ...
Vesicular neurotransmitter transporters in Huntington's disease: Initial observations and comparison with traditional synaptic markers
(John Wiley & Sons, Inc., 2001-09-15)
Markers of identified neuronal populations have previously suggested selective degeneration of projection neurons in Huntington's disease (HD) striatum. Interpretations are, however, limited by effects of compensatory ...
Insulin-like growth factor-I (IGF-I) and IGF binding protein-5 in Schwann cell differentiation
(John Wiley & Sons, Inc., 1997-05)
Schwann cells (SCs) are the myelin producing cells of the peripheral nervous system. During development, SCs cease proliferation and differentiate into either a myelin-forming or non-myelin forming mature phenotype. We are ...
6-Hydroxydopamine lesions of the nigrostriatal pathway alter the expression of glutamate decarboxylase messenger RNA in rat globus pallidus projection neurons
(Elsevier, 1992-12)
In situ hybridization was used to study the effect of 6-hydroxydopamine-induced damage to the midbrain dopaminergic neurons on the level of glutamate decarboxylase mRNA in globus pallidus neurons in the rat. Some animals ...
Two types of quisqualate receptors are decreased in human olivopontocerebellar atrophy cerebellar cortex
(Elsevier, 1990-07-23)
We used receptor autoradiography to study the distribution of ionotropic and metabotropic quisqualate (QA) receptors in normal human cerebellar cortex and cerebellar cortex from 7 cases of olivopontocerebellar atrophy ...
Rapid retrograde transport of proteins in sensory neurons in rats
(Elsevier, 1985-10-21)
Twenty-four hours following the injection of N-succinimidyl[2,3-3H]propionate into rat sciatic nerve, labeled protein appeared in the ipsilateral dorsal root ganglia. Autoradiography showed that the labeled proteins were ...
Insulin-like growth factor-I induces the phosphorylation and nuclear exclusion of forkhead transcription factors in human neuroblastoma cells
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-08)
Akt-mediated phosphorylation of forkhead transcription factors is linked to growth factor-stimulated cell survival. We investigated whether the survival activity of insulin-like growth factor-I (IGF-I) in SH-SY5Y human ...
Functional imaging with positron emission tomography in multiple system atrophy
(Springer-Verlag; Springer-Verlag/Wien, 2005-12)
Although the current guidelines for the clinical diagnosis of multiple system atrophy (MSA) do not require structural or functional brain imaging, investigations utilizing positron emission tomography (PET) have been helpful ...