Now showing items 1-10 of 20
Effectiveness factor calculations for immobilized enzyme catalysts
(Wiley Subscription Services, Inc., A Wiley Company, 1973-09)
The steady state, nonlinear diffusion equations which describe reactions in constrained enzyme solutions are of great interest in many biological and engineering applications. As in other types of nonlinear differential ...
Effects of serum and insulin-like growth factors on human neuroblastoma cell growth
(Elsevier, 1993-10-20)
Insulin-like growth factors (IGF-I and IGF-II) are mitogenic polypeptides expressed in both developing and adult tissues. To examine the effects of IGFs on neuronal growth, we used SH-SY5Y neuroblastoma cells as an in vitro ...
Gene expression of the insulin-like growth factors and their receptors in cultured human retinal pigment epithelial cells
(Elsevier, 1992-01)
Insulin-like growth factors I and II (IGF I and II) are polypeptides with both growth-promoting and insulin-like metabolic effects16,27. Immunoreactive IGF I is present in the retina14 and both IGF I and II are present in ...
Further localization of a gene for paroxysmal dystonic choreoathetosis to a 5-cM region on chromosome 2q34
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-01)
Paroxysmal dystonic choreoathetosis (PDC) is a rare neurological disorder characterized by episodes of involuntary movement, involving the extremities and face, which may occur spontaneously or be precipitated by caffeine, ...
Excitatory amino acidergic pathways and receptors in the basal ganglia
(Springer-Verlag, 1991-10)
The striatum receives the majority of excitatory amino acidergic input to the basal ganglia from neocortical and allocortical sources. The subthalamic nucleus and the substantia nigra also receive excitatory amino acidergic ...
mnd2: A New Mouse Model of Inherited Motor Neuron Disease
(Elsevier, 1993-06)
The autosomal recessive mutation mnd2 results in early onset motor neuron disease with rapidly progressive paralysis, severe muscle wasting, regression of thymus and spleen, and death before 40 days of age. mnd2 has been ...
Gene expression of the insulin-like growth factors and their receptors in human neuroblastoma cell lines
(Elsevier, 1992-10)
Insulin-like growth factors (IGF) I and II are polypeptides with both growth-promoting and insulin-like metabolic effects. The developmentally specific expression of IGF I and II in the nervous system implies a role for ...
IGF receptor function and regulation in autocrine human neuroblastoma cell growth
(Elsevier, 1993-10-20)
Insulin-like growth factor-II (IGF-II) and its receptors (type I and II IGF receptors) are expressed in the nervous system in a tissue and developmentally specific manner. We have previously shown that SH-SY5Y human ...
Glutamate transmission and toxicity in alzheimer's disease
(Elsevier, 1988)
1. 1. Despite intensive research, the cause of Alzheimer's disease is unknown.2. 2. Glutamate is the major excitatory transmitter of the cerebral cortex and hippocampus and it appears to have an important role in learning ...
Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
(Springer-Verlag, 2006-04)
Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have suggested similar effects and correlated motor and cognitive ...