Now showing items 1-8 of 8
Effects of serum and insulin-like growth factors on human neuroblastoma cell growth
(Elsevier, 1993-10-20)
Insulin-like growth factors (IGF-I and IGF-II) are mitogenic polypeptides expressed in both developing and adult tissues. To examine the effects of IGFs on neuronal growth, we used SH-SY5Y neuroblastoma cells as an in vitro ...
Excitatory amino acidergic pathways and receptors in the basal ganglia
(Springer-Verlag, 1991-10)
The striatum receives the majority of excitatory amino acidergic input to the basal ganglia from neocortical and allocortical sources. The subthalamic nucleus and the substantia nigra also receive excitatory amino acidergic ...
IGF receptor function and regulation in autocrine human neuroblastoma cell growth
(Elsevier, 1993-10-20)
Insulin-like growth factor-II (IGF-II) and its receptors (type I and II IGF receptors) are expressed in the nervous system in a tissue and developmentally specific manner. We have previously shown that SH-SY5Y human ...
Hand-arm frequency-weighted vibration effects on tactility
(Elsevier, 1990-07)
This study reports results of an investigation into the short-term effects of power hand tool vibration on deep sense tactile sensitivity. Five subjects operated a simulated hand tool using a 30 s / 30 s work / rest duty ...
Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs
(Kluwer Academic Publishers; Springer Science+Business Media, 2004-11)
Objectives : CCI-779 is an ester of the immunosuppressive agent sirolimus (rapamycin) that causes cell-cycle arrest at G1 via inhibition of key signaling pathways resulting in inhibition of RNA translation. Antitumor ...
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-08)
Purpose : Loss of PTEN, which is common in glioblastoma multiforme (GBM), results in activation of the mammalian target of rapapmycin (mTOR), thereby increasing mRNA translation of a number of key proteins required for ...
Quantitative characterization of hemodynamic properties and vasculature dysfunction of high-grade gliomas
(John Wiley & Sons, Ltd., 2007-10)
Aberrations in tumor and peritumoral vasculature may not be distinguishable by cerebral blood flow (CBF) or cerebral blood volume (CBV) alone. The relationships between CBF and CBV were examined to estimate vasculature-specific ...
Aligned electrospun nanofibers specify the direction of dorsal root ganglia neurite growth
(Wiley Subscription Services, Inc., A Wiley Company, 2007-12-01)
Nerve injury, a significant cause of disability, may be treated more effectively using nerve guidance channels containing longitudinally aligned fibers. Aligned, electrospun nanofibers direct the neurite growth of immortalized ...