Now showing items 21-30 of 74
The role of oxygen radicals in immune complex injury
(Elsevier, 1988)
In this review we will summarize our current understanding of the mediation of immune complex induced tissue injury. Comparisons will be made between the mediation of IgG versus IgA immune complex injury with emphasis on ...
Memory T lymphocyte hyporesponsiveness to non-cognate stimuli: a key factor in age-related immunodeficiency
(WILEY-VCH Verlag GmbH, 1992-04)
Previous studies from our laboratory have suggested that aging leads to an accumulation of cells expressing high levels of CD44, thought to be a marker for memory lymphocytes, and that positively selected CD44 hi T cells, ...
Rapid analysis of leukocyte-endothelial adhesion
(Elsevier, 1993-02-26)
Neutrophil adherence to endothelial monolayers in multi-well plates can be rapidly quantitated, using a fluorescent plate reader. The number of adherent neutrophils which have been labeled with biscarboxyethyl carboxyfluorescein ...
Products of cultured neuroglial cells: II. The production of fibronectin by C6 glioma cells
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1985-05)
The possibility of fibronectin production by C6 glioma cells was examined with assays which require protein synthesis. Proteins produced by C6 cells using radiolabeled amino acid precursors were tested for affinity to ...
The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity
(WILEY-VCH Verlag, 2008-08)
Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines, but the immune mechanisms that are activated by alum remain poorly understood. Alum has recently been shown to promote caspase-1 activation and ...
The chemokine receptor CCR6 is an important component of the innate immune response
(WILEY-VCH Verlag, 2007-09)
In our initial studies we found that naÏve CCR6-deficient (CCR6 –/– ) C57BL/6 mice possessed significantly lower number of both F4/80 + macrophages and dendritic cells (DC), but higher number of B cells in the peritoneal ...
Xaf1 can cooperate with TNFα in the induction of apoptosis, independently of interaction with XIAP
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2006-06)
XIAP-associated factor 1 (Xaf1) binds XIAP and re-localizes it to the nucleus, thus inhibiting XIAP activity and enhancing apoptosis [1]. Xaf1 expression is reduced or absent in tumor samples and cell lines suggesting it ...
Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells
(WILEY-VCH Verlag, 2007-08)
The molecular chaperone heat shock protein 90 (Hsp90) affects the function of many oncogenic signaling proteins including nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expressed in anaplastic large cell lymphoma (ALCL). ...
Rescue of Degradation-Prone Mutants of the FK506-Rapamycin Binding (FRB) Protein with Chemical Ligands
(WILEY-VCH Verlag, 2007-07-09)
We recently reported that certain mutations in the FK506-rapamycin binding (FRB) domain disrupt its stability in vitro and in vivo (Stankunas et al. Mol. Cell , 2003 , 12 , 1615). To determine the precise residues that ...
Chemical Biology: Learning through Case Studies . By Herbert Waldmann and Petra Janning .
(WILEY-VCH Verlag, 2009-10-12)
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