Now showing items 11-20 of 25
Heparin inhibits the growth of astrocytes in vitro
(Elsevier, 1988-05-03)
Heparin at a concentration of 100 [mu]g/ml, inhibits neonatal rat astrocyte proliferation by 45%, and [3H]thymidine incorporation into DNA by 55% when they are stimulated with 2% fetal bovine serum (FBS) in culture. Higher ...
The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain
(Elsevier, 1986-10-30)
To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/l [mu]l) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis ...
Ontogenesis of corticotropes and lactotropes in situ in the pituitary gland of the hamster
(Springer-Verlag, 1986-09)
The development of corticotropes and lactotropes was investigated in the golden Syrian hamster using an anti-porcine ACTH antiserum and a homologous antihamster PRL antiserum. Oval corticotropes were first visible in the ...
Zellweger syndrome: Diagnostic assays, syndrome delineation, and potential therapy
(Wiley Subscription Services, Inc., A Wiley Company, 1986-05)
Patients with the cerebrohepatorenal syndrome of Zellweger lack peroxisomes and certain peroxisomal enzymes such as dihydroxyacetone phosphate acyltransferase in their tissues. Deficiency of this enzyme, which is necessary ...
Hypoxia-ischemia produces focal disruption of glutamate receptors in developing brain
(Elsevier, 1987-07)
We examined the impact of a perinatal hypoxic-ischemic insult on the distribution of glutamate receptors in developing brain. We used a well characterized rodent model for perinatal hypoxic-ischemic encephalopathy, unilateral ...
Terminal deletion of the long arm of chromosome 2 in a mildly dysmorphic hypotonic infant with karyotype 46,XY,del(2)(q37)
(Wiley Subscription Services, Inc., A Wiley Company, 1989-03)
We describe a boy with severe hypotonia and minor facial anomalies with a terminal deletion of chromosome 2q (46,XY,del(2)(q37)). Comparison with previous cases in the literature indicates that this particular deletion ...
Neurotoxicity of is markedly enhanced in developing rat central nervous system
(Elsevier, 1988-08-30)
The neurotoxic lesion produced by direct injection of 25 nmol of (NMDA) into the corpus striatum of 7-day-old rats was compared to the effects of injecting 75 nmol into the striatum or hippocampus of adults. The area of ...
HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damage
(Elsevier, 1989-09-25)
The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats ...
Muscarinic cholinergic receptors in human infant forebrain: [3H]Quinuclidinyl benzilate binding in homogenates and quantitative autoradiography in sections
(Elsevier, 1985-04)
The ontogeny of muscarinic receptors in human brain was studied by comparing [3H]quinuclidinyl benzilate ([3H]QNB) binding in postmortem tissue from infants 1 week to 3 months of age with binding in adult specimens. ...
Effect of glycine and glycine receptor antagonists on NMDA-induced brain injury
(Elsevier, 1989-12-15)
In postnatal day 7 rats, a unilateral intrastriatal injection of 12.5 nmol of (NMDA) reproducibly injures the ipsilateral striatum, adjacent hippocampus and overlying cortex. The severity of injury can be quantified by ...