Now showing items 31-40 of 51
Hypoxia-ischemia produces focal disruption of glutamate receptors in developing brain
(Elsevier, 1987-07)
We examined the impact of a perinatal hypoxic-ischemic insult on the distribution of glutamate receptors in developing brain. We used a well characterized rodent model for perinatal hypoxic-ischemic encephalopathy, unilateral ...
Perinatal Hypoxia-Ischemia Disrupts Striatal High-Affinity [ 3 H]Glutamate Uptake into Synaptosomes
(Blackwell Publishing Ltd, 1986-11)
: We examined the impact of hypoxia-ischemia on high-affinity [ 3 H]glutamate uptake into a synaptosomal fraction prepared from immature rat corpus striatum. In 7-day-old pups the right carotid artery was ligated, and pups ...
Excitatory Amino Acids Contribute to the Pathogenesis of Perinatal Hypoxic-Ischemic Brain Injury
(Blackwell Publishing Ltd, 1992-07)
Inhibition of Nitric Oxide Synthase Activity Attenuates Striatal Malonate Lesions in Rats
(Blackwell Science Ltd, 1995-05)
Mitochondrial inhibitors such as malonate are potent neurotoxins in vivo. Intrastriatal injections of malonate result in neuronal damage reminiscent of “excitotoxic” lesions produced by compounds that activate NMDA receptors. ...
Perinatal Hypoxic-Ischemic Brain Injury Enhances Quisqualic Acid-Stimulated Phosphoinositide Turnover
(Blackwell Publishing Ltd, 1988-08)
In an experimental model of perinatal hypoxic-ischemic brain injury, we examined quisqualic acid (Quis)-stimulated phosphoinositide (PPI) turnover in hippocampus and striatum. To produce a unilateral forebrain lesion in ...
N -Methyl-D-Aspartate-Mediated Injury Enhances Quisqualic Acid-Stimulated Phosphoinositide Turnover in Perinatal Rats
(Blackwell Publishing Ltd, 1992-09)
Previous work in our laboratory demonstrated that ischemic-hypoxic brain injury in postnatal day 7 rats causes a substantial increase in phosphoinositide (PPI) turnover stimulated by the glutamate analogue quisqualic acid ...
Transient Hypoxia Alters Striatal Catecholamine Metabolism in Immature Brain: An In Vivo Microdialysis Study
(Blackwell Publishing Ltd, 1990-02)
Microdialysis probes were inserted bilaterally into the striatum of 7-day-old rat pups (n = 30) to examine extracellular fluid levels of dopamine, its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic ...
Neurotoxicity of is markedly enhanced in developing rat central nervous system
(Elsevier, 1988-08-30)
The neurotoxic lesion produced by direct injection of 25 nmol of (NMDA) into the corpus striatum of 7-day-old rats was compared to the effects of injecting 75 nmol into the striatum or hippocampus of adults. The area of ...
HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damage
(Elsevier, 1989-09-25)
The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats ...
The Role of the Hippocampal Mineralocorticoid and Glucocorticoid Receptors in the Hypothalamo-Pituitary-Adrenal Axis of the Aged Fisher Rat
(Elsevier, 1994-10)
The aging process has been frequently associated with hippocampal neuredegeneration, loss of corticosteroid receptors, and, at the same time, dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis. We were interested ...