Now showing items 11-20 of 23
Systemic administration of mk-801 protects against in perinatal rats
(Elsevier, 1990)
MK-801, a non-competitive antagonist of glutamate receptors, was tested for its ability to antagonize excitotoxic actions of or quisqualic acid injected into the brains of seven-day-old rats. Stereotaxic injection of ...
The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain
(Elsevier, 1986-10-30)
To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/l [mu]l) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis ...
Interferon-Γ inhibits DNA synthesis and insulin-like growth factor-II expression in human neuroblastoma cells
(Wiley Subscription Services, Inc., A Wiley Company, 1993-04-01)
Interferon-Γ (IFN-Γ) is known to be an antiproliferative, differentiation agent in many cell types, including neuroblastoma. In this study, we determined the effects of IFN-Γ on cellular growth and expression of insulin-like ...
Pulsatile LH secretion in women with premenstrual syndrome (PMS): Evidence for normal neuroregulation of the menstrual cycle
(Elsevier, 1992)
The premenstrual syndrome (PMS) has been proposed to result from excessive exposure to and/or withdrawal of brain opioid activity during the luteal phase. Because hypothalamic opioids are believed to modulate GnRH secretion, ...
Resistance to nitroprusside neurotoxicity in perinatal rat brain
(Elsevier, 1994-05-19)
Nitric oxide (NO) may mediate some of the toxic effects of the excitatory amino acid (EAA) glutamate when there is overactivation of the (NMDA) receptor. In the developing rodent nervous system, NMDA neurotoxicity peaks ...
Hypoxia-ischemia produces focal disruption of glutamate receptors in developing brain
(Elsevier, 1987-07)
We examined the impact of a perinatal hypoxic-ischemic insult on the distribution of glutamate receptors in developing brain. We used a well characterized rodent model for perinatal hypoxic-ischemic encephalopathy, unilateral ...
HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damage
(Elsevier, 1989-09-25)
The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats ...
The Role of the Hippocampal Mineralocorticoid and Glucocorticoid Receptors in the Hypothalamo-Pituitary-Adrenal Axis of the Aged Fisher Rat
(Elsevier, 1994-10)
The aging process has been frequently associated with hippocampal neuredegeneration, loss of corticosteroid receptors, and, at the same time, dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis. We were interested ...
Muscarinic cholinergic receptors in human infant forebrain: [3H]Quinuclidinyl benzilate binding in homogenates and quantitative autoradiography in sections
(Elsevier, 1985-04)
The ontogeny of muscarinic receptors in human brain was studied by comparing [3H]quinuclidinyl benzilate ([3H]QNB) binding in postmortem tissue from infants 1 week to 3 months of age with binding in adult specimens. ...
Effect of glycine and glycine receptor antagonists on NMDA-induced brain injury
(Elsevier, 1989-12-15)
In postnatal day 7 rats, a unilateral intrastriatal injection of 12.5 nmol of (NMDA) reproducibly injures the ipsilateral striatum, adjacent hippocampus and overlying cortex. The severity of injury can be quantified by ...