Now showing items 1-10 of 82
Characterization of gastrin amidation in the rat and porcine antrum: comparison with the pituitary
(Elsevier, 1990-04-24)
The formation of biologically active gastrin from glycine-extended processing intermediates occurs via the action of a peptide [alpha]-amidating enzyme. The observation that gastrin exists primarily as unamidated precursors ...
Use of mycophenolate mofetil in steroid-dependent and -resistant nephrotic syndrome
(Springer-Verlag; IPNA, 2003-08)
Cyclosporin (Cs-A) is an effective treatment for difficult cases of nephrotic syndrome (NS), but its use can be complicated by renal toxicity and a high incidence of relapses after withdrawal. We reviewed the charts of 10 ...
Primary preventive health care in children with heart disease
(Springer-Verlag, 1983-10)
In order to evaluate the preventive health care practices in children with heart disease, 499 families were surveyed in outpatient settings. Data were collected on 215 children with heart disease and 284 control children ...
Identification of the human CYS1 gene and candidate gene analysis in Boichis disease
(Springer-Verlag; IPNA, 2003-06)
Recessive mutations cause cystic kidney disease and a variable degree of biliary liver fibrosis in cpk mice. Recently, the responsible murine gene ( Cys1 ) was identified and expression in renal cilia demonstrated. Here ...
Effects of serum and insulin-like growth factors on human neuroblastoma cell growth
(Elsevier, 1993-10-20)
Insulin-like growth factors (IGF-I and IGF-II) are mitogenic polypeptides expressed in both developing and adult tissues. To examine the effects of IGFs on neuronal growth, we used SH-SY5Y neuroblastoma cells as an in vitro ...
Neoral induction in pediatric renal transplantation
(Springer-Verlag; IPNA - International Pediatric Nephrology Association New York, USA, 1998-01)
Neoral was instituted in pediatric renal transplant patients with the hypothesis it would have more predictable kinetics than Sandimmun. However, significant questions have arisen concerning potential toxicity and dosing ...
Follicle-stimulating hormone signal transduction: Role of carbohydrate in aromatase induction in immature rat Sertoli cells
(Elsevier, 1991-08)
Receptor activated adenylate cyclase acts as a major transmembrane signalling system. It is widely accepted that upon binding to its receptor, follicle-stimulating hormone (FSH) activates the cAMP-dependent pathway which ...
Pulmonary vascular changes associated with hypoplastic left ventricle syndrome
(Springer-Verlag, 1980-12)
The lungs of ten newborn infants who died of hypoplastic left ventricle syndrome were studied by a morphometric technique that (1) determined the percentage wall thickness of injected pulmonary arteries, (2) determined the ...
Gene expression of the insulin-like growth factors and their receptors in cultured human retinal pigment epithelial cells
(Elsevier, 1992-01)
Insulin-like growth factors I and II (IGF I and II) are polypeptides with both growth-promoting and insulin-like metabolic effects16,27. Immunoreactive IGF I is present in the retina14 and both IGF I and II are present in ...