Now showing items 1-10 of 14
Neuroprotective effects of MK-801, TCP, PCP and CPP against induced neurotoxicity in an in vivo perinatal rat model
(Elsevier, 1989-06-19)
Three non-competitive antagonists (MK-801, TCP, PCP) and one competitive antagonist (CPP) of (NMDA) receptors, were compared for their ability to antagonize neurotoxic actions of NMDA injected into the brains of 7-day-old ...
Glutamate recognition sites in human fetal brain
(Elsevier, 1988-01-22)
We used in vitro autoradiography with [3H]glutamate to examine the distribution of glutamate recognition sites in 18 and 21 week gestation human fetal brains. We found a wide distribution of [3H]glutamate binding in both ...
Heparin inhibits the growth of astrocytes in vitro
(Elsevier, 1988-05-03)
Heparin at a concentration of 100 [mu]g/ml, inhibits neonatal rat astrocyte proliferation by 45%, and [3H]thymidine incorporation into DNA by 55% when they are stimulated with 2% fetal bovine serum (FBS) in culture. Higher ...
The glutamate analogue quisqualic acid is neurotoxic in striatum and hippocampus of immature rat brain
(Elsevier, 1986-10-30)
To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/l [mu]l) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis ...
Ontogenesis of corticotropes and lactotropes in situ in the pituitary gland of the hamster
(Springer-Verlag, 1986-09)
The development of corticotropes and lactotropes was investigated in the golden Syrian hamster using an anti-porcine ACTH antiserum and a homologous antihamster PRL antiserum. Oval corticotropes were first visible in the ...
Hypoxia-ischemia produces focal disruption of glutamate receptors in developing brain
(Elsevier, 1987-07)
We examined the impact of a perinatal hypoxic-ischemic insult on the distribution of glutamate receptors in developing brain. We used a well characterized rodent model for perinatal hypoxic-ischemic encephalopathy, unilateral ...
Neurotoxicity of is markedly enhanced in developing rat central nervous system
(Elsevier, 1988-08-30)
The neurotoxic lesion produced by direct injection of 25 nmol of (NMDA) into the corpus striatum of 7-day-old rats was compared to the effects of injecting 75 nmol into the striatum or hippocampus of adults. The area of ...
HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damage
(Elsevier, 1989-09-25)
The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats ...
Muscarinic cholinergic receptors in human infant forebrain: [3H]Quinuclidinyl benzilate binding in homogenates and quantitative autoradiography in sections
(Elsevier, 1985-04)
The ontogeny of muscarinic receptors in human brain was studied by comparing [3H]quinuclidinyl benzilate ([3H]QNB) binding in postmortem tissue from infants 1 week to 3 months of age with binding in adult specimens. ...
Effect of glycine and glycine receptor antagonists on NMDA-induced brain injury
(Elsevier, 1989-12-15)
In postnatal day 7 rats, a unilateral intrastriatal injection of 12.5 nmol of (NMDA) reproducibly injures the ipsilateral striatum, adjacent hippocampus and overlying cortex. The severity of injury can be quantified by ...