Now showing items 1-10 of 25
Human neutrophils permeabilized with digitonin respond with lysosomal enzyme release when exposed to micromolar levels of free calcium
(Elsevier, 1986-04-08)
We have recently reported that human neutrophils can be permeabilized with the cholesterol complexing agent saponin and that these cells can be induced to secrete the granule enzyme lysozyme in response to micromolar levels ...
Neuroprotective effects of MK-801, TCP, PCP and CPP against induced neurotoxicity in an in vivo perinatal rat model
(Elsevier, 1989-06-19)
Three non-competitive antagonists (MK-801, TCP, PCP) and one competitive antagonist (CPP) of (NMDA) receptors, were compared for their ability to antagonize neurotoxic actions of NMDA injected into the brains of 7-day-old ...
Toxicity from treatment of neuroblastoma with 131 I-meta-iodobenzylguanidine
(Springer-Verlag, 1988-09)
Toxic effects from 131 I-meta-iodobenzylguanidine ( 131 I-MIBG) treatments of neuroblastoma in six patients were recorded. The toxicity was largely confined to the hematologic system where circulating leukocytes and platelets ...
Photodiode array ultraviolet spectrophotometric profiling of carboxylic acids in physiological fluids
(Elsevier, 1985)
In this paper the use of a computer-controlled photodiode array spectrophotometric detector for the high-performance liquid chromatographic (HPLC) profiling of carboxylic acids in physiological fluids is reported. The ...
Protein microinjection by protease permeabilization of fibroblasts
(Elsevier, 1988-07)
Exposure of cultured diploid fibroblasts to protease solutions induces a hyperpermeable state which permits entry of exogenous macromolecules directly into the cytosol. We have exploited this finding to devise a microinjection ...
Changes in protein kinase C activity are associated with the differentiation of Friend erythroleukemia cells
(Elsevier, 1987-02-18)
We investigated the activity and cellular distribution of protein kinase C during the dimethylsulfoxide (DMSO) and hypoxanthine-induced differentiation of Friend murine erythroleukemia cells. Most of the cellular protein ...
Elevated temperature produces cystine depletion in cystinotic fibroblasts
(Elsevier, 1986-12-10)
Increasing the incubation temperature of cystinotic fibroblasts to 40 or 43[deg]C produces a 70-80% decrease in lysosomal cystine content within 24-48 h. This effect is probably mediated by an altered substrate affinity ...
Glutamate recognition sites in human fetal brain
(Elsevier, 1988-01-22)
We used in vitro autoradiography with [3H]glutamate to examine the distribution of glutamate recognition sites in 18 and 21 week gestation human fetal brains. We found a wide distribution of [3H]glutamate binding in both ...
Cardiac controlled release for arrhythmia therapy: Lidocaine-polyurethane matrix studies
(Elsevier, 1988-12)
Cardiac arrhythmias are the principal cause of sudden death due to heart disease, and current therapy is inadequate. A novel approach for formulating a lidocaine-polyurethane controlled release matrix and implanting this ...