Now showing items 1-10 of 24
Gene expression of the insulin-like growth factors and their receptors in cultured human retinal pigment epithelial cells
(Elsevier, 1992-01)
Insulin-like growth factors I and II (IGF I and II) are polypeptides with both growth-promoting and insulin-like metabolic effects16,27. Immunoreactive IGF I is present in the retina14 and both IGF I and II are present in ...
Short-Term Adrenalectomy Increases Glucocorticoid and Mineralocorticoid Receptor mRNA in Selective Areas of the Developing Hippocampus
(Elsevier, 1993-10)
In the central nervous system, adrenal steroids bind to two different types of corticosteroid receptors: glucocorticoid (GR) or mineralocorticoid (MR). In vitro biochemical and autoradiographic techniques have been used ...
Gene expression of the insulin-like growth factors and their receptors in human neuroblastoma cell lines
(Elsevier, 1992-10)
Insulin-like growth factors (IGF) I and II are polypeptides with both growth-promoting and insulin-like metabolic effects. The developmentally specific expression of IGF I and II in the nervous system implies a role for ...
Magnesium reduces (NMDA)-mediated brain injury in perinatal rats
(Elsevier, 1990-02-05)
We evaluated the neuroprotective effects of systemically administered magnesium against (NMDA)-mediated brain injury in perinatal rats. Postnatal day (PND) 7 rats received unilateral intrastriatal injections of 25 nmol ...
The microsomal calcium-ATPase inhibitor thapsigargin is a neurotoxin in perinatal rodent brain
(Elsevier, 1992-10-12)
Thapsigargin is a potent inhibitor of the microsomal calcium-ATPase. We hypothesized that thapsigargin-induced liberation of calcium from sequestered intracellular sites could result in irreversible brain injury. To assess ...
MK-801 pretreatment enhances brain injury and increases brain recognition site binding in rats
(Elsevier, 1990)
Direct intracerebral administration of typically produces focal brain injury. (+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-immine maleate (MK-801), a non-competitive antagonist, can protect against -mediated ...
Effect of depolarization on striatal amino acid efflux in perinatal rats: An in vivo microdialysis study
(Elsevier, 1991-07-08)
We used in vivo microdialysis to determine if infusion of depolarizing concentrations of potassium stimulated striatal excitatory amino acid (EAA) efflux in post-natal day (PND) 7 rats. Dialysis probes were perfused with ...
Prenatal Exposure of the Ovine Fetus to Androgens Sexually Differentiates the Steroid Feedback Mechanisms That Control Gonadotropin Releasing Hormone Secretion and Disrupts Ovarian Cycles
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-02)
Exposure of the female sheep fetus to exogenous testosterone in early pregnancy permanently masculinizes the reproductive neuroendocrine axis. Specifically, in utero androgens given to female lambs from day 30 to 90 of a ...
Expression of Corticotropin-Releasing Hormone Transgenes in Neurons of Adult and Developing Mice
(Elsevier, 1994-12)
The DNA sequences important for cell-specific expression and developmental regulation of corticotropin-releasing hormone (CRH) were analyzed in transgenic mice. A construct containing 0.5 kb of CRH 5' flanking DNA linked ...
Accumulated glutamate levels in the synaptic vesicle are not maintained in the absence of active transport
(Elsevier, 1990-03-14)
We have investigated factors which may affect accumulated glutamate levels in synaptic vesicles and glutamate efflux. Agents which dissipate the electrochemical proton gradient resulted in a rapid reduction of steady-state ...