Now showing items 21-30 of 78
Presence of multiple protein kinase activities in rat liver nuclei
(Elsevier, 1972-02-25)
Protein kinase activity was found in the acidic nuclear protein fraction extracted from rat liver nuclei. Four distinct kinase activities were separated by phosphocellulose and DEAE-Sephadex chromatography. Additional ...
Effects of various psychotomimetic agents on the eeg and acetylcholine release from the cerebral cortex of brainstem transected cats
(Elsevier, 1972-09)
The effects of i.v. administration of [Delta]9 THC, phencyclidine, the pyrrolidyl and piperidyl isomers of Ditran, and LSD-25 were determined on the spontaneous neocortical EEG and release of acetylcholine (ACh) from the ...
Composition of the aqueous phase of chromaffin granules
(Elsevier, 1979-09-20)
Nuclear magnetic resonance spectroscopy has been used to determine the composition of the aqueous phase of bovine chromaffin granules. Relative concentrations of catecholamines (epinephrine plus norepinephrine), ATP and ...
Variable interval responding maintained by intravenous codeine and ethanol injections in the rhesus monkey
(Elsevier, 1976-11)
Rhesus monkeys were trained to respond under a variable interval 2 min schedule for codeine or ethanol injections. Both codeine and ethanol were effective in the initiation of variable-interval responding; responding was ...
Inhibition of RNA polymerase and formyltetrahydrofolate synthetase activity by 6-chloro-8-aza-9-cyclopentylpurine. Structure-activity relationships
(Elsevier, 1970-04-02)
The structural requirements for inhibition of bacterial RNA polymerase and rabbit liver formyltetrahydrofolate synthetase activity by a series of purine nucleoside analogs related to 6-chloro-8-aza-9-cyclopentylpurine (689) ...
Failure of potassium canrenoate to alter experimentally induced digitalis arrhythmias
(Elsevier, 1973-06)
The antiarrhythmic effects of potassium canrenoate were examined under in vivo and in vitro conditions. In the pentobarbital anesthetized dog, ventricular tachycardia was produced by the i.v. administration of ouabain, ...
Alteration of enzyme activity in rat liver following the acute and chronic administration of nicotine
(Elsevier, 1970-05)
The ip injection of nicotine (2 or 4 mg/kg) to rats produced an increase in tryptophan pyrrolase activity in liver within 2 hours after drug administration. The elevation in enzyme activity reached a peak at 4 hours after ...
Changes in locomotor activity and naloxone-induced jumping in mice produced by WIN 35,197-2 (Ethylketazocine) and morphine
(Springer-Verlag, 1978-01)
Acute i.p. administration of morphine or cocaine produced increase in locomotor activity in Swiss-Webster female mice that were maximal at 32–100 mg/kg for morphine and at 32 mg/kg for cocaine. WIN 35,197-2 produced ...
The effect of hemicholinium-3 on the in vivo formation of cerebral phosphatidylcholine
(Elsevier, 1970-02-10)
The effect of hemicholinium-3 on the incorporation of [Me-18C]choline into the phospholipids of the subcellular fractions of the canine caudate nucleus was studied. A correlation between the amount of hemicholinium-3 ...