Now showing items 121-130 of 130
A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A 2 with ceramide transacylase activity
(Kluwer Academic Publishers; Springer Science+Business Media, 2003-01)
A series of inhibitors of glucosylceramide synthesis, the PDMP based family of compounds, has been developed as a tool for the study of sphingolipid biochemistry and biology. During the course of developing more active ...
Electrospray sample deposition for matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry with attomole detection limits
(John Wiley & Sons, Ltd., 2004-06-15)
Electrospray sample deposition was explored for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). In this method, nanoliter volumes of matrix/analyte mixture were electrosprayed ...
Antalarmin, a putative CRH-RI antagonist, has transient reinforcing effects in rhesus monkeys
(Springer-Verlag, 2002-11)
Abstract
Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells
(Blackwell Publishing Ltd, 2009-01)
Expression and regulation of voltage-gated sodium channel β1 subunit protein in human gliosis-associated pathologies
(Springer-Verlag, 2003-05)
Auxiliary β1 subunits of voltage-gated sodium channels (NaChs) critically regulate channel activity and may also act as cell adhesion molecules (CAMs). In a recent study we have shown that the expression of β1 NaCh protein ...
Effect of pharmacogenetics on medicine
(John Wiley & Sons, Inc., 2001)
Pharmacogenetics is moving rapidly to assemble a large set of polymorphisms that define the influence of genetic diversity on human drug response. Scientific and technological advances of the last 10 years have led to new ...
Assessment of ifosfamide pharmacokinetics, toxicity, and relation to CYP3A4 activity as measured by the erythromycin breath test in patients with sarcoma
(Wiley Subscription Services, Inc., A Wiley Company, 2007-06-01)
BACKGROUND. Ifosfamide is a chemotherapeutic agent that requires cytochrome P450 3A (CYP3A) for bioactivation and metabolism. To the authors' knowledge, the correlation between dose, pharmacokinetics, CYP3A, and toxicity ...
Coupling Efficacy and Selectivity of the Human Μ-Opioid Receptor Expressed as Receptor—GΑ Fusion Proteins in Escherichia coli
(Blackwell Science Ltd., 2000-09)
Disposition of WR-1065 in the liver of tumor-bearing rats following regional vs systemic administration of amifostine
(John Wiley & Sons, Ltd., 2004-01)
Purpose —Amifostine is a prodrug in which selectivity is largely determined by the preferential formation and uptake of its cytoprotective metabolite, WR-1065, in normal tissues as a result of differences in membrane-bound ...
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-02)
Rationale : By acting on peripheral opioid receptors, opioid agonists can attenuate nociceptive responses induced by a variety of agents. Objectives : This study was conducted to characterize capsaicin-induced thermal ...