Now showing items 11-20 of 130
Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/ neu in synovial sarcoma Presented, in part, at the 7th Connective Tissue Oncology Society Meeting, West Palm Beach, Florida, November 1–3, 2001.
(Wiley Subscription Services, Inc., A Wiley Company, 2005-02-15)
BACKGROUND Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology. The majority of synovial sarcomas harbor a specific chromosomal translocation ...
Multi-Log Cytotoxicity of Carbocyclic 2′-Deoxyguanosine in HSV-TK-Expressing Human Tumor Cells
(Mary Ann Liebert, Inc., publishers, 2002-03-01)
Ganciclovir (GCV) is widely used as a prodrug for selective activation in tumor cells expressing herpes simplex virus thymidine kinase (HSV-TK) because of its ability to induce multi-log cytotoxicity to HSV-TK-expressing ...
Direct monitoring pressure overload predicts cardiac hypertrophy in mice
(IOP Publishing Ltd, 2007-11-01)
Pressure overload (POL) is a classical model for studying cardiac hypertrophy, but there has been no direct measure of hemodynamics in a conscious ambulatory mouse model of POL. We used abdominal aortic constriction to ...
Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme
(Springer-Verlag, 2006-07)
Purpose : This study sought to determine the maximum tolerated dose of flat-dosed vinorelbine in combination with capecitabine in patients with metastatic breast cancer. At the time of study initiation, it was anticipated ...
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
(Kluwer Academic Publishers; Springer, 2005-06)
Tamoxifen has been a mainstay of adjuvant therapy for breast cancer for many years. We sought to determine if genetic variability in the tamoxifen metabolic pathway influenced overall survival in breast cancer patients ...
Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition
(Wiley Subscription Services, Inc., A Wiley Company, 2006-05-01)
Background The role of erbB tyrosine kinases, especially Her-2, in osteosarcoma has engendered intense debate. Some investigators identified an association between low-level Her-2 expression, compared to none, and poor ...
Mediation of adenylyl cyclase sensitization by PTX-insensitive Gα oA , Gα i1 , Gα i2 or Gα i3
(Blackwell Publishing Ltd, 2006-12)
Chronic activation of mu-opioid receptors, which couple to pertussis toxin-sensitive Gα i/o proteins to inhibit adenylyl cyclase (AC), leads to a compensatory sensitization of AC. Pertussis toxin-insensitive mutations of ...
Convulsant activity of a non-peptidic δ-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats
(Springer-Verlag, 2002-10)
Abstract
Removal of High-Molecular-Weight DNA by Carboxylated Magnetic Beads Enhances the Detection of Mutated K-ras DNA in Urine
(Blackwell Publishing Inc, 2008-08)
Consensus statement: Expedition Inspiration 2004 Breast Cancer Symposium ‘Breast Cancer – the Development and Validation of New Therapeutics’
(Kluwer Academic Publishers; Springer, 2005-03)