Now showing items 21-30 of 130
Microscale sample deposition onto hydrophobic target plates for trace level detection of neuropeptides in brain tissue by MALDI-MS
(John Wiley & Sons, Ltd., 2005-10)
A sample preparation method that combines a modified target plate with a nanoscale reversed-phase column (nanocolumn) was developed for detection of neuropeptides by matrix-assisted laser desorption/ionization time-of-flight ...
Evaluation of Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
(Kluwer Academic Publishers; Springer Science+Business Media, 2004-01)
The epidermal growth factor system is a well characterized growth factor receptor pathway, the deregulation of which has been be associated with neoplastic growth. Overexpression or amplification of the epidermal growth ...
Elevated serum vascular endothelial growth factor and decreased survival in advanced laryngeal carcinoma
(Wiley Subscription Services, Inc., A Wiley Company, 2002-11)
Purpose. The purpose of this study was to determine whether serum vascular endothelial growth factor (s-VEGF) levels at the time of diagnosis correlate with any known tumor variables and overall survival in patients with ...
Mechanism of Action and Structural Requirements of Constrained Peptide Inhibitors of RGS Proteins
(Blackwell Publishing Ltd, 2006-04)
Dysplasia in Barrett esophagus
(Wiley Subscription Services, Inc., A Wiley Company, 2004-04-15)
BACKGROUND Dysplasia in Barrett esophagus is a premalignant condition that is associated with an increased risk of developing esophageal adenocarcinoma. Unfortunately, clinical investigation aimed at prevention of progression ...
Regulation of Myo-Inositol Homeostasis in Differentiated Human NT2-N Neurons
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-05)
We have investigated the possible role of second messengers on inositol homeostasis in NT2-N cells, human central nervous system neurons obtained by terminal differentiation of teratocarcinoma precursors. Uptake of inositol ...
Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance
(Blackwell Science Ltd, 2002-08)
Inositol phospholipids and inositol phosphates mediate well-established functions in signal transduction and in Ca 2+ homeostasis in the CNS and non-neural tissues. More recently, there has been renewed interest in other ...
Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse
(Springer-Verlag, 2005-09)
Drug challenges in “intact” and p -chlorophenylalanine ( p -CPA)-treated animals can be used to distinguish agents that act as direct serotonin (5-HT) agonists from agents that function as 5-HT releasers.
Self-administration of fentanyl, cocaine and ketamine: effects on the pituitary–adrenal axis in rhesus monkeys
(Springer-Verlag, 2004-11)
Drugs of abuse can affect the functioning of the hypothalamic–pituitary–adrenal (HPA) axis. Acute administration of drugs that serve as reinforcers have been observed to stimulate the rat HPA axis, leading to the suggestion ...
Clinical and Radiologic Assessments to Predict Breast Cancer Pathologic Complete Response to Neoadjuvant Chemotherapy
(Kluwer Academic Publishers; Springer, 2005-08)
To prospectively compare the ability of clinical examination, mammography, vascularity-sensitive ultrasound, and magnetic resonance imaging (MRI) to determine pathologic complete response (CR) in breast cancer patients ...