Now showing items 11-20 of 72
Effects of Osmolality and Ionic Strength on Secretion from Adrenal Chromaffin Cells Permeabilized with Digitonin
(Blackwell Publishing Ltd, 1986-06)
Hyperosmotic solutions inhibit exocytosis of catecholamine from adrenal chromaffin cells at a step after Ca 2+ entry into the cells. The possibility that the inhibition resulted from an inability of shrunken secretory ...
Effects of chronic and acute treatment of antipsychotic drugs on calmodulin release from rat striatal membranes
(Elsevier, 1980-03)
Chronic treatment of rats with the antipsychotic drugs haloperidol and (+)-butaclamol results in supersensitivity of striatal dopamine (DA) receptors. Striatal membranes of these animals have an increased content of an ...
Properties of a CDP-Diglyceride Hydrolase from Guinea Pig Brain
(Blackwell Publishing Ltd, 1981-03)
Enzymatic hydrolysis of the pyrophosphate bond of CDP-diglyceride (CDP-DG), previously shown to occur in bacteria, is demonstrable in mammalian tissues. Activity was enriched in a lysosomal fraction obtained from guinea ...
Regulation of Calmodulin- and Dopamine-Stimulated Adenylate Cyclase Activities by Light in Bovine Retina
(Blackwell Publishing Ltd, 1984-06)
Neural retina from most species contains 3,4-dihydroxyphenylethylamine (dopamine) receptors coupled to stimulation of adenylate cyclase activity. It has been demonstrated that release of dopamine from its neurons and ...
Effect of ethanol and of noise on reaction time in the monkey: Variation with stimulus level
(Springer-Verlag, 1980-06)
To determine whether the latency-increasing effects of ethanol were differential with respect to the intensity of the stimulus that initiated the response, three rhesus monkeys were trained on a behavioral task in which ...
[alpha]2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment
(Elsevier, 1981-04-06)
After two weeks of twice-daily administration of amitriptyline to rats, the binding of [3H]clonidine to presynaptic [alpha]2-adrenoreceptors was decreased in membranes isolated from 5 areas of the rat brain. After one day ...
ATP-Dependent Glutamate Uptake into Synaptic Vesicles from Cerebellar Mutant Mice
(Blackwell Publishing Ltd, 1988-10)
The ATP-dependent glutamate uptake system in synaptic vesicles prepared from mouse cerebellum was characterized, and the levels of glutamate uptake were investigated in the cerebellar mutant mice, staggerer and weaver, ...
Changes occur in central adrenoreceptor function following long-term morphine treatment and during morphine withdrawal
(Elsevier, 1984-12)
Radioloigand binding techniques were used in combination with electrophysiological recording to characterize changes in beta adrenoreceptor activity in various brain areas in rats treated chronically with morphine. Following ...
Comparison of "selective" opiate receptor antagonists on the isolated mouse vas deferens
(Elsevier, 1984-12)
The selectivity and relative potencics of opiate receptor antagonists were compared on the mouse vas deferens preparation. ICI-174864 was found to be a highly selective antagonist at delta opiate receptors equal in potency ...
Enhanced Coupling of Neonatal Muscarinic Receptors in Rat Brain to Phosphoinositide Turnover
(Blackwell Publishing Ltd, 1987-06)
The relationship between the density of the muscarinic receptor in developing rat cerebral cortex and its coupling to phosphoinositide turnover is examined. Tissue slices from rats of various ages were incubated with myo- ...