Now showing items 11-20 of 75
Reduction of myocardial infarct size by neutrophil depletion: Effect of duration of occlusion
(Elsevier, 1986-10)
Experiments were performed in the dog to examine the effects of neutropenia on ultimate infarct size resulting from short (90 minutes) or prolonged (4 hours) circumflex coronary artery occlusion. Sheep antiserum to canine ...
Establishment and characterization of UM-EC-2, a tamoxifen-sensitive, estrogen receptor-negative human endometrial carcinoma cell line,
(Elsevier, 1990-05)
UM-EC-2 was established from a patient with poorly differentiated stage IB endometrial carcinoma. This cell line produces tumors in nude mice that have the same histological features as the patient's tumor. UM-EC-2 cells ...
Bretylium: A prototype for future development of antidysrhythmic agents
(Elsevier, 1983-08)
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
(Kluwer Academic Publishers; Springer, 2005-06)
Tamoxifen has been a mainstay of adjuvant therapy for breast cancer for many years. We sought to determine if genetic variability in the tamoxifen metabolic pathway influenced overall survival in breast cancer patients ...
Electrophysiologic actions of pirmenol in dogs with recent myocardial infarction
(Elsevier, 1986-10)
The electrophysiologic actions of pirmenol, an investigational class I antiarrhythmic agent, were evaluated in eight anesthetized dogs, 5 to 10 days after anterior myocardial infarction. Before administration of the drug, ...
Protective Effects of the SOD-mimetic SC-52608 Against Ischemia/Reperfusion Damage in the Rabbit Isolated Heart
(Elsevier, 1994-08)
An experimental model of myocardial ischemia/reperfusion injury was used to assess the cardioprotective effects of SC-52608, a low molecular weight superoxide dismutase mimetic. Langendorff perfused rabbit isolated hearts ...
Consensus statement: Expedition Inspiration 2004 Breast Cancer Symposium ‘Breast Cancer – the Development and Validation of New Therapeutics’
(Kluwer Academic Publishers; Springer, 2005-03)
Evaluation of Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
(Kluwer Academic Publishers; Springer Science+Business Media, 2004-01)
The epidermal growth factor system is a well characterized growth factor receptor pathway, the deregulation of which has been be associated with neoplastic growth. Overexpression or amplification of the epidermal growth ...
A rapid attenuation of muscarinic agonist stimulated phosphoinositide hydrolysis precedes receptor sequestration in human SH-SY-5Y neuroblastoma cells
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-05)
Agonist occupancy of muscarinic cholinergic receptors in human SH-SY-5Y neuroblastoma cells elicited two kinetically distinct phases of phosphoinositide hydrolysis when monitored by either an increased mass of inositol ...
Repeated haloperidol increases both calmodulin and a calmodulin-binding protein in rat striatum
(Elsevier, 1994-12)
Repeated treatment with the antipsychotic drug, haloperidol, leads to an increased behavioral sensitivity to dopamine agonists exhibited upon withdrawal from the drug. An increase in the particulate content of the endogenous ...