Now showing items 21-30 of 75
The role of the neutrophil and free radicals in ischemic myocardial injury
(Elsevier, 1989-12)
Scintigraphic detection of regional disruption of adrenergic neurons in the heart
(Elsevier, 1988-07)
Experiments were designed to detect regional disruptions of adrenergic neurons in the hearts of living dogs. The neuron disruption was achieved by the application of phenol to the epicardium of the left ventricle. Evidence ...
Long-term intravenous infusion of antiarrhythmic drugs using a totally implanted drug delivery system
(Elsevier, 1982-06)
In vitro and in vivo testing was performed to establish the feasibility of a totally implantable pump system to deliver antiarrhythmic agents. In vitro flow characteristics suggested predictable day to day delivery with ...
Regulation of Myo-Inositol Homeostasis in Differentiated Human NT2-N Neurons
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-05)
We have investigated the possible role of second messengers on inositol homeostasis in NT2-N cells, human central nervous system neurons obtained by terminal differentiation of teratocarcinoma precursors. Uptake of inositol ...
Ibuprofen-mediated infarct size reduction: Effects on regional myocardial function in canine myocardial infarction
(Elsevier, 1982-10)
Normal, marginal, and central ischemic regional myocardial function were evaluated in a canine model of myocardial infarction during 90 minute left circumflex coronary artery occlusion in 25 anesthetized dogs randomly ...
Recombinant single-chain urokinase-type plasminogen activator (rscu-pa) induces thrombolysis and systemic fibrinolysis in a canine model of coronary artery thrombosis
(Elsevier, 1988-07-01)
The thrombolytic efficacy of recombinant single-chain urokinase-type plasminogen activator (rscu-PA) was studied in an open-chest canine model of coronary artery thrombosis. Dogs (n=16) were anesthetized, a left thoracotomy ...
Ventricular fibrillation resulting from ischemia at a site remote from previous myocardial infarction : A conscious canine model of sudden coronary death
(Elsevier, 1982-12)
In anesthetized dogs, a 30 gauge silver wire was inserted into the lumen of the left circumflex (LC) coronary artery and myocardial ischemic injury was produced by subsequent occlusion of the left anterior descending (LAD) ...
Clinical and Radiologic Assessments to Predict Breast Cancer Pathologic Complete Response to Neoadjuvant Chemotherapy
(Kluwer Academic Publishers; Springer, 2005-08)
To prospectively compare the ability of clinical examination, mammography, vascularity-sensitive ultrasound, and magnetic resonance imaging (MRI) to determine pathologic complete response (CR) in breast cancer patients ...
Pharmacological Characterization of 4-hydroxy- N -desmethyl Tamoxifen, a Novel Active Metabolite of Tamoxifen
(Kluwer Academic Publishers; Springer Science+Business Media, 2004-05)
The antiestrogen tamoxifen is extensively metabolized in patients to form a series of compounds with altered affinity for estrogen receptors (ERs), the primary target of this drug. Furthermore, these metabolites exhibit a ...
Electrophysiologic effects of disopyramide phosphate on reentrant ventricular arrhythmia in conscious dogs after myocardial infarction
(Elsevier, 1980-11)
The electrophysiologic actions of disopyramide phosphate on reentrant ventricular tachycardia induced by premature ventricular stimuli were evaluated in conscious dogs 2 to 4 days after myocardial infarction. Disopyramide ...