Now showing items 11-20 of 88
The reinforcing property of ethanol in the rhesus monkey
(Springer-Verlag, 1978-01)
Rhesus monkeys received intravenous injections of ethanol during daily sessions contingent on their presses on an available lever. Under the standard conditions, when each response on the lever during a 3-h period each day ...
Some thoughts on the relations between animal and human drug-taking
(Elsevier, 1983)
1. 1. Results of studies of drug self-administration have frequently been suggested as indicators of the potential for abuse of these drugs by humans. Historical data (pre 1970), although scant, supported this suggestion ...
Effects of morphine, nalorphine and naloxone on neocortical release of acetylcholine in the rat
(Springer-Verlag, 1973-06)
The effects of morphine (10 mg/kg), nalorphine (1 and 10 mg/kg), and naloxone (1 mg/kg) were studied on the neocortical release of acetylcholine (ACh) in midpontine pretrigeminal transected rats. Morphine and, to a lesser ...
A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats
(Springer-Verlag, 1987-09)
Directly observable behavioral effects of the N-methyl- D -aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovalerate (AP5) (10–1,000 mg/kg IP, 0.18–5.6 μmol/rat ICV) and of phencyclidine (PCP) (3.2–56 mg/kg IP, ...
Effects of stress and REM sleep deprivation on the patterns of avoidance learning and brain acetylcholine in the mouse
(Springer-Verlag, 1973-12)
Pure bred DBA/2J mice were subjected to varying degrees of stress and “water tank” REM sleep deprivation using one-animal cages, large platforms and/or poles. Subsequently, the animals were studied for acquisition, short-term ...
Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons
(Springer-Verlag, 1985-03)
Six pigeons, trained to peck a response key on a fixed-ratio 20 schedule of food reinforcement, were used to examine the effects of morphine, naltrexone, and dextrorphan, before, during, and after chronic treatment with ...
Fenfluramine and N-ethyl amphetamine: Comparison of the reinforcing and rate-decreasing actions in the rhesus monkey
(Springer-Verlag, 1975-01)
N-ethyl amphetamine HCl (NEA) and fenfluramine HCl ( meta -trifluoromethyl N-ethyl amphetamine) were evaluated as reinforcers in rhesus monkeys that had been previously trained to press a lever using food presentations and ...
Competitive and uncompetitive N -methyl- d -aspartate antagonist discriminations in pigeons: CGS 19755 and phencyclidine
(Springer-Verlag, 1995-03)
The purpose of the present studies was to examine representative uncompetitive and competitive NMDA antagonists, as well as the glycine/NMDA antagonist, HA 966, in pigeons trained to discriminate either PCP or CGS 19755 ...
Effects of d -amphetamine, scopolamine, chlordiazepoxide and diphenylhydantoin on self-stimulation behavior and brain acetylcholine
(Springer-Verlag, 1972-03)
The effects of d-amphetamine (0.25–8), scopolamine (0.25–8), chlordiazepoxide (2.5–40), and diphenylhydantoin (25–75), given i.p. or s.c. on a mg/kg basis, were studied on self-stimulation behavior in the male albino rat. ...
Cocaine, d -amphetamine, and pentobarbital effects on responding maintained by food or cocaine in rhesus monkeys
(Springer-Verlag, 1979-09)
The effects of IM injections of cocaine, d -amphetamine, and pentobarbital were studied in rhesus monkeys whose lever-press responding was maintained under a second-order fixed-interval, fixed ratio schedule of reinforcement. ...