Now showing items 11-17 of 17
Comparison of the adrenalytic activity of mitotane and a methylated homolog on normal adrenal cortex and adrenal cortical carcinoma
(Springer-Verlag, 1993-11)
Mitotane is an important adrenalytic drug for the treatment of adrenal cancer whose use is limited by toxicity. Reports from another laboratory indicated that a methylated homolog of Mitotane (Mitometh) tested in guinea ...
Bisquaternary ammonium compounds as potential tumor imaging agents
(Elsevier, 1979)
Reports of rapid accumulation of 3H- or 14C-labelled hexamethonium in cartilaginous tissues after intravenous administration to rats and mice and of binding of hexamethonium to chondroitin sulfate in vitro prompted synthesis ...
Enhanced cytotoxicity with methotrexate in conjunction with hypoxanthine in L1210 cells in culture
(Springer-Verlag, 1988-07)
By inhibiting dihydrofolate reductase, methotrexate (MTX) depletes cellular stores of reduced folates, resulting in the inhibition of DNA and RNA synthesis. Inhibition of RNA synthesis arrests cells in the G 1 phase of the ...
The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′-deoxycytidine
(Springer-Verlag, 2003-10)
Cytotoxicity from the anticancer drug 2′,2′-difluoro-2′-deoxycytidine (dFdCyd) has been correlated with its incorporation into DNA. However, cytotoxicity may also result from inhibition of DNA synthesis, due to either (1) ...
The cytokinetic and cytotoxic effects of ICRF-159 and ICRF-187 in vitro and ICRF-187 in human bone marrow in vivo
(Kluwer Academic Publishers; Martinus Nijhoff Publishers ; Springer Science+Business Media, 1983-12)
The cytotoxic and cytokinetic effects of ICRF-159 and its d-enantiomer ICRF-187 have been examined in vitro . The effects of both agents were identical. Cytotoxicity is dependent on both the drug concentration and the ...
Inhibition of fludarabine metabolism by arabinosylcytosine during therapy
(Springer-Verlag, 1992-05)
The active 5′-triphosphate of arabinosyl-2-fluoroadenine (F-ara-ATP) increases the anabolism of arabinosylcytosine (ara-C), whereas ara-C 5′-triphosphate inhibits the phosphorylation of arabinosyl-2-fluoroadenine (F-ara-A) ...
Adrenal proteins bound by a reactive intermediate of mitotane
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1997-02)
Purpose : Mitotane ( o,p ′-DDD), is the only adrenolytic agent available for the treatment of adrenocortical carcinoma. Previous studies have shown that mitotane covalently binds to adrenal proteins following its metabolism ...