Now showing items 11-20 of 35
Accumulated glutamate levels in the synaptic vesicle are not maintained in the absence of active transport
(Elsevier, 1990-03-14)
We have investigated factors which may affect accumulated glutamate levels in synaptic vesicles and glutamate efflux. Agents which dissipate the electrochemical proton gradient resulted in a rapid reduction of steady-state ...
Mu-Opioid receptors modulate noradrenaline release from the rat hippocampus as measured by brain microdialysis
(Elsevier, 1994-02-04)
The modulation of noradrenaline (NA) release via presynaptic opioid receptors in the hippocampus of freely moving rats was studied by the use of brain microdialysis. Extracellular levels of NA were estimated by assaying ...
[alpha]2-Adrenoceptor modulation of 5-HT biosynthesis in the rat brain
(Elsevier, 1992-05-11)
The purpose of the present study is to clarify the modulation of the biosynthesis of serotonin (5-HT) via the [alpha]2-adrenoceptors in the brain. For this purpose. 5-hydroxytryptophan (5-HTP) accumulation was determined ...
Electrophysiological responsiveness to isoproterenol in rat hippocampal slices correlates with changes in [beta]-adrenergic receptor density induced by chronic morphine treatment
(Elsevier, 1989-04-17)
The effects of chronic morphine treatment and morphine withdrawal on [beta]-adrenergic receptor density and electrophysiological responsiveness in rat hippocampus were examined. Chronic treatment of rats with morphine for ...
Analgesic, anesthetic, and respiratory effects of the competitive (NMDA) antagonist CGS 19755 in rhesus monkeys
(Elsevier, 1990-09-03)
The competitive excitatory amino acid antagonist cis-4-phosphonomethyl-2-piperidine-carboxylic acid (CGS 19755) increased the latency for monkeys to remove their tails from warm water (analgesia); larger doses produced ...
Glutamate uptake system in the presynaptic vesicle: Glutamic acid analogs as inhibitors and alternate substrates
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1993-01)
A variety of naturally occurring amino acids, their isomers, and synthetic analogs were tested for their ability to inhibit uptake of [ 3 H]glutamate into presynaptic vesicles from bovine cerebral cortex. Strongest inhibition ...
Ontogeny of glutamate accumulating activity in rat brain synaptic vesicles
(Elsevier, 1989-02-13)
The relationship between the ontogeny of the vesicular glutamate uptake system and synaptogenesis in rats was investigated. For this purpose we have developed a simplified procedure for the preparation of crude synaptic ...
Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801,
(Elsevier, 1994-08)
Chronic administration of a psychomotor stimulant has been shown to produce progressively enhanced effects, a phenomenon called "reverse tolerance" or sensitization. Sensitization which develops to the psychomotor stimulant ...
Regional distribution of some enzymes involved with putative neurotransmitters in the human visual system
(Elsevier, 1973-08-17)
Levels of protein and activity of several enzymes were determined in different portions of the visual system of the human brain. The enzymes studied were total cholinesterase (TChE), acetylcholinesterase (AChE), ...