Now showing items 1-10 of 130
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
Diabetic neuropathy: inhibitory G protein dysfunction involves PKC-dependent phosphorylation of G oα
(Blackwell Science Ltd, 2003-08)
We examined the hypothesis that decreased inhibitory G protein function in diabetic neuropathy is associated with increased protein kinase C (PKC)-dependent phosphorylation of the G oα subunit. Streptozotocin-induced ...
A Role for the Small Molecular Weight GTPases, Rho and Cdc42, in Muscarinic Receptor Signaling to Focal Adhesion Kinase
(Blackwell Science Ltd., 2000-05)
Conditional ablation and recovery of forebrain neurogenesis in the mouse
(Wiley Subscription Services, Inc., A Wiley Company, 2009-06-20)
Forebrain neurogenesis persists throughout life in the rodent subventricular zone (SVZ) and hippocampal dentate gyrus (DG). Several strategies have been employed to eliminate adult neurogenesis and thereby determine whether ...
Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
(Springer-Verlag, 2005-11)
Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression ...
Chemoprevention of Colon Cancer: Current Status and Future Prospects
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-12)
Colorectal cancer is an important public health problem in the western world. Although some progress has been made in the prevention and management of this disease, colon cancer still remains one of the most common types ...
Human papillomavirus infection in “young” versus “old” patients with squamous cell carcinoma of the head and neck
(John Wiley & Sons, Inc., 2000-10)
Background Human papillomavirus (HPV) represents a potential risk factor for squamous cell cancer of the head and neck (SCCHN). We evaluated the prevalence of HPV DNA in patients with SCCHN diagnosed at the University of ...
Analysis of the Late Steps of Exocytosis: Biochemical and Total Internal Reflection Fluorescence Microscopy (TIRFM) Studies
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2006-04-20)
1. Time with Julie in his laboratory at the NIH in the early 1970s is remembered. The experience led to a life-long interest in the regulation of catecholamine secretion. Here are summarized aspects of this work.