Now showing items 1-10 of 166
β-funaltrexamine antagonizes the discriminative stimulus effects of morphine but not naltrexone in pigeons
(Springer-Verlag, 1987-02)
Antagonistic actions of the irreversible, μ-selective antagonist β-funaltrexamine (β-FNA) were evaluated in pigeons trained to discriminate among intramuscular injections of morphine (5.6 mg/kg), saline, and naltrexone ...
A specific radioimmunoassay for androstenedione with reduced bridge-binding
(Elsevier, 1984-09)
Antibody used in a steroid radioimmunoassay raised against a steroid hapten-carrier protein conjugate may recognize both the hapten and the chemical bridge to the protein. Use of the same bridge in the radioisotopic label ...
Short-term effects of marijuana smoking on cognitive behavior in experienced male users
(Springer-Verlag, 1973-03)
The effects of smoking marijuana on the ability to use abstract concepts was tested in 12 experienced marijuana users. Each subject was tested three times, after smoking prepared 300 mg cigarettes containing either 0, 1.5 ...
Effects of tobacco smoking on the topographic EEG I
(Elsevier, 1994-09)
1. 1. The EEG and cardiovascular effects of smoking tobacco cigarettes of varying nicotine content were studied in Japanese chronic tobacco smokers.2. 2. Thirteen female and fifteen male adult normal volunteers were recruited ...
Some effects of muscarinic cholinergic blocking drugs on behavior and the electrocorticogram
(Springer-Verlag, 1964-03)
Results are presented for the effects of drugs with muscarinic cholinergic blocking actions, both central and peripheral (scopolamine and 1-hyoscyamine) and primarily peripheral (methyl atropine and methyl scopolamine), ...
A method to reduce interference by sucrose in the detection of thiobarbituric acid-reactive substances
(Elsevier, 1984-03)
A thiobarbituric acid (TBA) reaction for measuring lipid peroxidation products was evaluated for interference by several ingredients commonly used in solutions to prepare or analyze tissue homogenates or subcellular ...
Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
(Springer-Verlag, 2005-11)
Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression ...
Glucocorticoid-reinforced responding in the rhesus monkey
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-11)
Rationale: Glucocorticoids have been reported to have rewarding effects in rats and may lead to drug-seeking behavior in humans under some circumstances. Objectives: The present study investigated whether glucocorticoids ...
Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat
(Springer-Verlag, 1979-01)
The narcotic antagonist naloxone was tested to determine its possible interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained to press a bar on a fixed-ratio ...
Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-09)
Purpose : We have reported previously that the expression of E. coli dUTPase (dutE) can protect HT29 cells from 5-fluorodeoxyuridine (FdUrd)-induced DNA fragmentation and cytotoxicity. In the study reported here, we further ...