Now showing items 1-10 of 75
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
Prevention of ventricular fibrillation by bretylium in a conscious canine model of sudden coronary death
(Elsevier, 1983-05)
In anesthetized dogs, a silver wire electrode was inserted into the lumen of the circumflex coronary artery (LCX) and myocardial infarction was produced by a temporary 90-minute occlusion of the left anterior descending ...
Antiarrhythmic versus antifibrillatory actions: Inference from experimental studies
(Elsevier, 1993-11-26)
Pathophysiology of the coronary circulation is a major contributor to altering the myocardial substrate, rendering the heart susceptible to the onset of arrhythmias associated with sudden cardiac death. Antiarrhythmic drug ...
Increase in experimental infarct size with digoxin in a canine model of myocardial ischemia-reperfusion injury
(Elsevier, 1988-06)
In the present study, dogs were pretreated with intravenous digoxin, 0.0125 mg/kg/day, for 6 to 7 consecutive days to achieve clinically relevant serum concentrations; untreated animals were used as control subjects. After ...
Nitroglycerin inhibits experimental thrombosis and reocclusion after thrombolysis
(Elsevier, 1994-04)
Nitroglycerin inhibits platelet aggregation in vitro, but its effect on thrombosis and platelet function in vivo is controversial. This study assessed the effect of nitroglycerin on primary thrombus formation in response ...
Electrical induction of coronary artery thrombosis in the ambulatory canine: A model for evaluation of anti-thrombotic agents
(Elsevier, 1980-03-15)
A simple technique for the reliable induction of coronary artery thrombosis in a conscious dog by delivery of low amperage electric current to the intimal surface of the artery is described. Ibuprofen, an agent known to ...
Purification and characterization of platelet aggregation inhibitors from snake venoms
(Elsevier, 1994-01-01)
Proteins that inhibit glycoprotein (GP) IIb/IIIa mediated platelet aggregation have been purified from the venom of two snake species. A small platelet aggregation inhibitor (pl.AI), multisquamatin (Mr=5,700), was purified ...
Antiplatelet monoclonal F(ab')2 antibody directed against the platelet GPIIb/IIIa receptor complex prevents coronary artery thrombosis in the canine heart
(Elsevier, 1989-04)
Interactions between platelets with injured vascular endothelium contribute to thrombotic occlusion. A murine monoclonal antibody [7E3 F(ab')2] to the platelet GPIIb/IIIa receptor complex was used to inhibit platelet ...
Cardioprotective effects of amlodipine in the ischemic-repefused heart
(Elsevier, 1989-11-07)
Amlodipine is a a dihydropyridine derivative belonging to the group of pharmacologic calcium entry blocking agents and is characterized as having a slow onset and relatively long duration of action with minimal effects on ...
Streptokinase improves reperfusion blood flow after coronary artery occlusion
(Elsevier, 1989-06)
Streptokinase is an effective thrombolytic agent which, with early restoration of coronary blood flow, has the potential for limiting infarct size. Distinct from thrombolysis, we studied the effects of streptokinase on ...