Now showing items 1-10 of 115
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
A specific radioimmunoassay for androstenedione with reduced bridge-binding
(Elsevier, 1984-09)
Antibody used in a steroid radioimmunoassay raised against a steroid hapten-carrier protein conjugate may recognize both the hapten and the chemical bridge to the protein. Use of the same bridge in the radioisotopic label ...
A method to reduce interference by sucrose in the detection of thiobarbituric acid-reactive substances
(Elsevier, 1984-03)
A thiobarbituric acid (TBA) reaction for measuring lipid peroxidation products was evaluated for interference by several ingredients commonly used in solutions to prepare or analyze tissue homogenates or subcellular ...
Chemoprevention of Colon Cancer: Current Status and Future Prospects
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-12)
Colorectal cancer is an important public health problem in the western world. Although some progress has been made in the prevention and management of this disease, colon cancer still remains one of the most common types ...
Synthesis of potential antiprogestogens
(Elsevier, 1976-01)
Acylated derivatives of 17[alpha]-hydroxyprogesterone were prepared in order to test the hypothesis that dialkylamino alkyl moieties have the effect of transforming progestogens into antiprogestogens. This approach has ...
The inhibitive effects of steroid analogues in the binding of tritiated 5[alpha]-dihydrotecto3terone to receptor proteins from rat prostate tissue
(Elsevier, 1975-02)
The relationship between molecular structure and the binding potential of steroids to receptor proteins was investigated. Twenty-four selected steroids were studied in minced incubations of rat pro state tissue. Measurements ...
Effects of dimethyl sulfoxide on the globally ischemic heart: Possible general relevance to hypothermic organ preservation
(Elsevier, 1982-02)
Isolated perfused rabbit hearts were made globally ischemic for 2 hr, then reperfused. For 5 min before and after ischemia hearts were perfused with hypothermic (20 or 27 [deg]C), hypoxic, substrate-free cardioplegic ...
Substitution and primary dependence studies in animals
(Elsevier, 1985-02)
The mixed agonist-antagonist analgesics buprenorphine, butorphanol, nalbuphine, pentazocine and picenadol were compared to the prototype mu and kappa agonists morphine and Mr 2033, respectively, in the following tests in ...
Paired-ion high-performance liquid chromatographic assay for plasma choline
(Elsevier, 1980-03-14)
Choline was isolated from deproteinized plasma by cation-exchange chromatography. Isolated choline was directly converted to the 3,5-dinitrobenzoate derivative and was analyzed by paired-ion high-performance liquid ...