Now showing items 1-10 of 602
Cholinergic Receptor-Mediated Phosphorylation and Activation of Tyrosine Hydroxylase in Cultured Bovine Adrenal Chromaffin Cells
(Blackwell Publishing Ltd, 1986-02)
We have identified a 56-kilodalton protein in cultured bovine adrenal chromaffin cells that is phos-phorylated when catecholamine secretion is stimulated. Immunodetection on Western blots from both one- and two-dimensional ...
β-funaltrexamine antagonizes the discriminative stimulus effects of morphine but not naltrexone in pigeons
(Springer-Verlag, 1987-02)
Antagonistic actions of the irreversible, μ-selective antagonist β-funaltrexamine (β-FNA) were evaluated in pigeons trained to discriminate among intramuscular injections of morphine (5.6 mg/kg), saline, and naltrexone ...
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
Naltrexone Reduces Ethanol- and/or Water-Reinforced Responding in Rhesus Monkeys: Effect Depends Upon Ethanol Concentration
(Blackwell Publishing Ltd, 1999-09)
The opioid antagonist naltrexone reduces responding for ethanol. If naltrexone produces this effect by blocking ethanol-induced opioid activity, then naltrexone should reduce responding for ethanol regardless of level of ...
Adrenergic status in anxiety disorders: Platelet alpha2-adrenergic receptor binding, blood pressure, pulse, and plasma catecholamines in panic and generalized anxiety disorders patients and in normal subjects,
(Elsevier, 1990-07-01)
In order to evaluate adrenergic function in anxiety disorders, platelet alpha2-adrenergic binding parameters and supine and standing blood pressure, pulse, and venous plasma epinephrine and norepinephrine were determined ...
Chronic haloperidol treatment increased calcium-dependent phosphorylation in rat striatum
(Elsevier, 1982-01-04)
In previous studies, we observed that when rats were chronically treated with haloperidol, there was a significant increase of calmodulin activity in their striatal membranes. Calmodulin is knwon to modulate calcium-dependent ...
Prevention of ventricular fibrillation by bretylium in a conscious canine model of sudden coronary death
(Elsevier, 1983-05)
In anesthetized dogs, a silver wire electrode was inserted into the lumen of the circumflex coronary artery (LCX) and myocardial infarction was produced by a temporary 90-minute occlusion of the left anterior descending ...
The effect of brainstem transection on blood pressure in the dog
(Elsevier, 1969-03-01)
Blood pressure was compared before and after midpontine pretrigeminal brainstem transection in the dog. Statistically significant decreases in blood pressure were observed 1/2, 1, and 1-1/2 hours after brainstem transection. ...
Electrolysis-induced myocardial dysfunction : A novel method for the study of free radical mediated tissue injury
(Elsevier, 1986-07)
Oxygen-derived free radicals and other oxidizing species are thought to be involved in inflammation and ischemic tissue injuries. Recently, oxygen-derived free radicals also have been implicated in tissue injury of the ...