Now showing items 1-6 of 6
Inhibition of Vesicular Glutamate Uptake by Rose Bengal-Related Compounds: Structure–Activity Relationship
(Kluwer Academic Publishers-Plenum Publishers; Springer Science+Business Media, Inc., 2005-03)
Synaptic vesicular accumulation of glutamate is a vital initial step in glutamate transmission. We have previously shown that Rose Bengal, a polyhalogenated fluorescein analog, is a potent inhibitor of glutamate uptake ...
Regulation of Myo-Inositol Homeostasis in Differentiated Human NT2-N Neurons
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2000-05)
We have investigated the possible role of second messengers on inositol homeostasis in NT2-N cells, human central nervous system neurons obtained by terminal differentiation of teratocarcinoma precursors. Uptake of inositol ...
Hypoxia modulates cholinergic but not opioid activation of G proteins in rat hippocampus
(Wiley Subscription Services, Inc., A Wiley Company, 2007-10)
Intermittent hypoxia, such as that associated with obstructive sleep apnea, can cause neuronal death and neurobehavioral dysfunction. The cellular and molecular mechanisms through which hypoxia alter hippocampal function ...
Nicotine effects on regional cerebral blood flow in awake, resting tobacco smokers
(John Wiley & Sons, Inc., 2000-12-01)
The hypothesis for this research was that regional cerebral blood flow (rCBF) would increase following nasal nicotine administration to overnight abstinent tobacco smokers in relationship to the known brain distribution ...
Simple transporter trafficking model for amphetamine-induced dopamine efflux
(Wiley Subscription Services, Inc., A Wiley Company, 2007-07)
Amphetamine and its derivatives are important drugs of abuse causing both short-term excitatory and long-term addictive effects. The short-term excitatory effects are linked to amphetamine's ability to maintain high levels ...
Estradiol attenuates the K + -induced increase in extracellular GABA in rat striatum
(Wiley Subscription Services, Inc., A Wiley Company, 2006-02)
Estradiol acts rapidly and directly to inhibit L-type Ca 2+ current in medium spiny neurons from striatum. Since medium spiny neurons contain Γ-aminobutyric acid (GABA), we hypothesized that estradiol inhibition of Ca 2+ ...