Now showing items 31-40 of 205
Changes in medial cortical blood flow with a stimulus-response compatibility task
(Elsevier, 1994-02)
Previous work has suggested that human subjects engaged in tasks, like the Stroop task, that require response selection utilize the medical frontal cortex. We used positron emission tomography to measure blood flow changes ...
Characterization of [11C]tetrabenazine as an in vivo radioligand for the vesicular monoamine transporter
(Elsevier, 1994-02)
[11C]Tetrabenazine ([11C]TBZ) is a new in vivo radioligand for positron emission tomographic (PET) imaging of vesicular monoamine transporters. The in vivo distribution, metabolism and pharmacological specificity of [11C]TBZ ...
Linkage of the multiple endocrine neoplasia type 2B gene (MEN2B) to chromosome 10 markers linked to MEN2A
(Elsevier, 1990-10)
The syndrome of multiple endocrine neoplasia type 2B (MEN 2B) resembles that of MEN 2A in that both include medullary carcinoma of the thyroid, pheochromocytoma, and autosomal dominant inheritance, but is distinct in that ...
Cardiovascular MR angiography
(Kluwer Academic Publishers; Springer Science+Business Media, 1999-04)
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
(Wiley Subscription Services, Inc., A Wiley Company, 1997-07)
This study investigated cerebral glucose metabolism in very early Alzheimer's disease, before a clinical diagnosis of probable Alzheimer's disease is possible, using [ 18 F]fluorodeoxyglucose positron emission tomography. ...
In vivo binding of [11C]tetrabenazine to vesicular monoamine transporters in mouse brain
(Elsevier, 1992)
The time course of regional mouse brain distribution of radioactivity after i.v. injection of a tracer dose of [11C]tetrabenazine ([11C]TBZ) has been determined. Radiotracer uptake into brain is rapid, with 3.2% injected ...
Oxidation of substituted 4-fluorobenzaldehydes: Application to the no-carrier-added syntheses of 4-[18F]fluoroguaiacol and 4-[18F]fluorocatechol
(Elsevier, 1991)
The synthesis of 4-[18F]fluoroguaiacol (4-[18F]fluoro-2-methoxyphenol) has been achieved in no-carrier-added form starting from 2-methoxy-4-nitrobenzaldehyde, using nucleophilic aromatic substitution by [18F]fluoride ...
Cerebral glucose hypermetabolism in Friedreich's ataxia detected with positron emission tomography
(Wiley Subscription Services, Inc., A Wiley Company, 1990-12)
Local cerebral metabolic rate for glucose was studied with 18 F-2-fluoro-2-deoxy-D-glucose and positron emission tomography (PET) in 22 patients with Friedreich's ataxia and 23 age-matched normal control subjects. The ...
Synthesis of a [11C]Methoxy derivative of [alpha]-Dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter
(Elsevier, 1993-12)
The synthesis of [11C]TBZOMe, a [11C]methoxy derivative at the 2-hydroxy position of [alpha]-dihydrotetrabenazine, was carried out by an O-[11C]methylation reaction. The product [11C]TBZOMe (100-200 mCi) was obtained in ...