Now showing items 11-20 of 56
Synthesis of [18F]flunarizine
(Elsevier, 1991)
Flunarizine, a calcium channel antagonist of the piperazine class, has been labeled with the positron-emitter 18F. 4-[18F]Fluoro-4'-fluorobenzhydryl chloride was prepared in three steps from no-carrier-added [18F]fluoride ...
Selective localization of radioiodinated alkylphosphocholine derivatives in tumors
(Elsevier, 1992-10)
We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimeth ...
Metabolic fate of the heart agent [18F]6-fluorometaraminol
(Elsevier, 1989)
Studies were performed to determine whether [18F]6-fluorometaraminol (18F-FMR), a new neuronal heart radiopharmaceutical, is metabolized in vivo and if the metabolites are taken up in heart. Rat, dog, baboon and guinea pig ...
Evaluation of ( E )-2′-deoxy-2′-(fluoromethylene)cytidine on the 9L rat brain tumor model using MRI
(John Wiley & Sons, Ltd., 2003-04)
( E )-2′-deoxy-2′-(fluoromethylene)cytidine (FMdC), was evaluated as a potential treatment for malignant gliomas using the rat 9L brain tumor model. FMdC was shown to be an effective inhibitor of cell proliferation in ...
Routine production of 2-deoxy-2-[18F]fluoro--glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin
(Elsevier, 1990)
Resin-supported [18F]fluoride ion has been prepared and applied to a rapid, convenient synthesis of [18F]FDG. "No-carrier-added" [18F]fluoride ion is collected on a quaternary 4-(N, N-dialkylamino)-pyridinium functionalized ...
Iodine-125 and fluorine-18 labeled aryl-1,4-dialkylpiperazines: Potential radiopharmaceuticals for in vivo study of the dopamine uptake system
(Elsevier, 1992-05)
A series of fluorine-18 and iodine-125 labeled aryl-1,4-dialkylpiperazine analogs, derivatives of GBR 12935, were synthesized as radiotracers for positron emission tomography or single photon emission computerized tomography ...
[18F]fluorination/decarbonylation: New route to aryl [18F]fluorides
(Elsevier, 1991)
A new route to aryl [18F]fluorides without electron withdrawing ring substituents has been developed. [18F]Fluorobenzaldehydes, prepared from no-carrier-added (NCA) [18F]fluoride using nucleophilic aromatic substitution ...
Use of DES-treated rats as an animal model for assessment of pituitary adenoma imaging agents
(Elsevier, 1986)
Prolactin (PRL) secreting pituitary adenomas are the most common type of pituitary tumors. An imaging agent which specifically localized in prolactinomas would be of considerable clinical value for both initial detection ...
Methoden fÜr den Einbau von Kohlenstoff-11 zur Erzeugung von Radiopharmaka fÜr die Positronenemissionstomographie
(WILEY-VCH Verlag, 2009-03-03)
No Abstract
Extraction of [18F]fluoride from [18O]water by a fast fibrous anion exchange resin
(Elsevier, 1990)
[18F]Fluoride for nucleophilic radiofluorination was recovered from target water by trapping on a fibrous anion exchange resin in the hydroxide form and subsequent displacement into wet methanolic K2CO3. Extraction into ...