Now showing items 21-30 of 51
Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats
(Blackwell Science Ltd, 2003-12)
The amygdala is an essential neural substrate for Pavlovian fear conditioning. Nevertheless, long-term synaptic plasticity in amygdaloid afferents, such as the auditory thalamus, may contribute to the formation of fear ...
Magnetic Resonance Imaging of Ethyl-nitrosourea-induced Rat Gliomas: A Model for Experimental Therapeutics of Low-grade Gliomas
(Kluwer Academic Publishers; Springer Science+Business Media, 2001-07)
Human low-grade gliomas represent a population of brain tumors that remain a therapeutic challenge. Preclinical evaluation of agents, to test their preventive or therapeutic efficacy in these tumors, requires the use of ...
Alexia without agraphia
(Springer-Verlag, 1992-05)
Two new cases of alexia without agraphia are presented. Pertinent clinical findings, anatomy, pathophysiology and differential diagnoses are reviewed. The importance of carefully examining the inferior portion of the left ...
Time-course of change in [ 11 C]carfentanil and [ 11 C]raclopride binding potential after a nonpharmacological challenge
(Wiley Subscription Services, Inc., A Wiley Company, 2007-09)
Positron Emission Tomography (PET) with appropriate radiotracers and quantification methods allows the detection of changes in endogenous neurotransmission by determine the reduction in the binding potential (BP) of receptors ...
Influence of body mass index on median nerve function, carpal canal pressure, and cross-sectional area of the median nerve
(Wiley Subscription Services, Inc., A Wiley Company, 2004-10)
Obese individuals have slowed conduction in the median nerve across the wrist, but the mechanism for this is not established. This case-control study of 27 obese subjects and 16 thin subjects was designed to test the ...
Assessment of muscarinic receptor concentrations in aging and Alzheimer disease with [ 11 C]NMPB and PET
(John Wiley & Sons, Inc., 2001-03-15)
Cerebral cholinergic deficits have been described in Alzheimer disease (AD) and as a result of normal aging. At the present time, there are very limited options for the quantification of cholinergic receptors with in vivo ...
Autoradiographic quantification of muscarinic cholinergic synaptic markers in bat, shrew, and rat brain
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-05)
We employed radioligand binding autoradiography to determine the distributions of pre- and postsynaptic cholinergic radioligand binding sites in the brains of two species of bat, one species of shrew, and the rat. High ...
Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification
(Kluwer Academic Publishers; Springer Science+Business Media, 1998-01)
Malignant gliomas have been associated with a high rate of glycolytic activity which is believed necessary to sustain cellular function and integrity. Since lonidamine (LND) is believed to reduce tumor glucose utilization ...
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders
(Springer-Verlag, 2001-10)
Rationale: There exists a wide range of animal models and measures designed to assess anxiety or fearfulness. However, the relationship between these models and clinical anxiety symptoms and syndromes is unclear. The ...
role of limbic system in the control of hamster growth
(Elsevier, 1979)
Rostral septal lesions accelerate somatic growth in adult hamsters. This study tested the hypothesis that this effect results from damage to fibers of passage by observing the effects of transections of septohippocampal ...