Now showing items 31-40 of 51
Effect of Aspartame-Derived Phenylalanine on Neutral Amino Acid Uptake in Human Brain: A Positron Emission Tomography Study
(Blackwell Publishing Ltd, 1991-05)
The possible effects of elevation of the plasma phe-nylalanine level secondary to the ingestion of aspartame on brain amino acid uptake in human subjects have been investigated by means of positron emission tomography ...
Localization of muscarinic M3 receptor protein and M3 receptor binding in rat brain
(Elsevier, 1994-11)
A family of receptor subtypes, defined either by molecular (ml-m5) or pharmacological (M1-M4) analysis, mediates muscarinic cholinergic neurotransmission in brain. The distribution and functions of the m3 receptor protein ...
Nicotine effects on regional cerebral blood flow in awake, resting tobacco smokers
(John Wiley & Sons, Inc., 2000-12-01)
The hypothesis for this research was that regional cerebral blood flow (rCBF) would increase following nasal nicotine administration to overnight abstinent tobacco smokers in relationship to the known brain distribution ...
( R )- N -[ 11 C]methyl-3-pyrrolidyl benzilate, a high-affinity reversible radioligand for PET studies of the muscarinic acetylcholine receptor
(Wiley Subscription Services, Inc., A Wiley Company, 2002-07)
We recently reported the synthesis and binding affinity of ligands for the muscarinic acetylcholine receptor (mAChR) based on both the pyrrolidyl and piperidyl benzilate scaffold. One of these, ( R )-3-pyrrolidyl benzilate, ...
Diffusion tensor imaging of the brain: review of clinical applications
(Springer-Verlag, 2004-05)
We review the theoretical background to diffusion tensor imaging (DTI) and some of its commoner clinical applications, such as cerebral ischemia, brain maturation and traumatic brain injury. We also review its potential ...
Rapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice
(John Wiley & Sons, Inc., 2000-03-15)
The dose- and time-dependent changes of in vivo radioligand binding to the neuronal membrane dopamine transporter (DAT) and vesicular monoamine transporter type 2 (VMAT2) were examined in mouse brain after MPTP ...
MR spectroscopy in the evaluation of recurrent contrast-enhancing lesions in the posterior fossa after tumor treatment
(Springer-Verlag, 2004-07)
Recurrent contrast-enhancing lesions arising within foci of prior brain neoplasms treated with chemotherapy and/or radiation therapy pose a significant diagnostic dilemma, as they may represent recurrent or residual tumor, ...
Massive symptomatic subependymoma of the lateral ventricles: case report and review of the literature
(Springer-Verlag, 2005-03)
Subependymomas are benign intraventricular tumors with an indolent growth pattern, which are usually asymptomatic, and most commonly occur in the fourth and lateral ventricles. When symptomatic, subependymomas often obstruct ...
Reduced MPTP neurotoxicity in striatum of the mutant mouse tottering
(John Wiley & Sons, Inc., 1998-10)
The effects of MPTP treatment (4 × 10 mg/kg, 2-h intervals) on in vivo striatal binding of (+)-α-[ 3 H]dihydrotetrabenazine ((+)-[ 3 H]DTBZ) to the vesicular monoamine transporter type 2 (VMAT2) were examined in wild type ...
[ 18 F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses
(John Wiley & Sons, Inc., 1998-11)
Loss of cholinergic transmission in the cortex and hippocampus is a characteristic feature of Alzheimer's disease, and visualization of functional cholinergic synapses in the brain with PET could be a useful method for ...