Now showing items 1-10 of 56
Synthesis and regional mouse brain distribution of [11C]Nisoxetine, a norepinephrine uptake inhibitor
(Elsevier, 1989)
Nisoxetine, a selective and high affinity (IC50 = 1 nM) inhibitor of NE reuptake, has been radiolabeled in high specific activity (> 600 Ci/mmol) by the alkylation of the nor-methyl precursor with [11C]CH3I. Synthetic ...
Direct optical resolution of vesamicol and a series of benzovesamicol analogues by high-performance liquid chromatography
(Elsevier, 1994-04-29)
The direct optical resolution of the vesicular acetylcholine uptake inhibitors vesamicol and benzovesamicol and nine benzovesamicol analogues were performed by HPLC on a commercially available cellulose tris(3,5-dimethylphenyl ...
In vivo 31 P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine kinase gene
(John Wiley & Sons, Ltd., 1996-12)
Phosphorus MRS was evaluated as a monitor of tumour therapeutic response to the herpes simplex virus thymidine kinase suicide gene therapy paradigm. In vivo 31 P spectra were obtained from subcutaneous rat C6 gliomas ...
Feasibility of sharpening limited-angle tomography by including an orthogonal set of projections
(Elsevier, 1982-02-15)
In single photon emission nuclear medicine, computed tomography systems that employ only a limited angular range of projection data suffer from blurring in the depth (or z) direction. With simulated data, we show that ...
Oxidation of substituted 4-fluorobenzaldehydes: Application to the no-carrier-added syntheses of 4-[18F]fluoroguaiacol and 4-[18F]fluorocatechol
(Elsevier, 1991)
The synthesis of 4-[18F]fluoroguaiacol (4-[18F]fluoro-2-methoxyphenol) has been achieved in no-carrier-added form starting from 2-methoxy-4-nitrobenzaldehyde, using nucleophilic aromatic substitution by [18F]fluoride ...
Synthesis of a [11C]Methoxy derivative of [alpha]-Dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter
(Elsevier, 1993-12)
The synthesis of [11C]TBZOMe, a [11C]methoxy derivative at the 2-hydroxy position of [alpha]-dihydrotetrabenazine, was carried out by an O-[11C]methylation reaction. The product [11C]TBZOMe (100-200 mCi) was obtained in ...
Adrenal cortical 11[beta]-hydroxylase and side-chain cleavage enzymes. requirement for the A- or B-pyridyl ring in metyrapone for inhibition
(Elsevier, 1985-01)
The adrenal cortical enzyme systems, 11[beta]-hydroxylase, P-45011[beta], and the side-chain cleavage complex, P-450 sec, differ only in their cytochrome P-450s. Structural modifications of metyrapone, an inhibitor of ...
Radioiodination via isotope exchange in pivalic acid
(Elsevier, 1986)
A variety of benzoic and aryl aliphatic mono and polyiodinated acids and esters (sterol, triglyceride) were radioiodinated in 55-99% radiochemical yield by isotope exchange with Na 125I in a melt of pivalic acid. In general, ...