Now showing items 41-50 of 83
Classifications of ovarian cancer tissues by proteomic patterns
(WILEY-VCH Verlag, 2006-11)
Ovarian cancer is a morphologically and biologically heterogeneous disease. The identification of type-specific protein markers for ovarian cancer would provide the basis for more tailored treatments, as well as clues for ...
Selective resonance enhanced multiphoton ionization of aromatic polymers in supersonic beam mass spectrometry
(Elsevier, 1991-07-15)
Various polymers have been studied using a pulsed laser evaporation method for volatilizing these species and entraining them into a supersonic jet expansion followed by resonance enhanced multiphoton ionization (REMPI) ...
Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing
(Springer-Verlag, 2006-03)
Obscurin is a recently identified giant multidomain muscle protein (∼800 kDa) whose structural and regulatory functions remain to be defined. The goal of this study was to examine the effect of obscurin gene silencing ...
A second generation human haplotype map of over 3.1 million SNPs
(Nature Publishing Group, 2007-10-18)
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP ...
Resonance enhanced multiphoton ionization of nucleosides by using pulsed-laser desorption in supersonic beam mass spectrometry
(Elsevier, 1989-04-01)
Pulsed-laser desorption is used as a means of volatilizing nucleosides into the gas phase for entrainment into a supersonic jet expansion. These species are then studied in a time-of-flight mass spectrometer by resonance ...
Elucidation of peptide metabolism by on-line immunoaffinity liquid chromatography mass spectrometry
(John Wiley & Sons, Ltd., 2000-02-29)
An immunoaffinity chromatography extraction capillary liquid chromatography separation has been coupled to electrospray ionization mass spectrometry for on-line characterization of drug metabolites of a therapeutic peptide ...
Intestinal intraepithelial lymphocyte derived angiotensin converting enzyme modulates epithelial cell apoptosis
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-12)
Background & Aims : Intestinal adaptation in short bowel syndrome (SBS) consists of increased epithelial cell (EC) proliferation as well as apoptosis. Previous microarray analyses of intraepithelial lymphocytes (IEL) gene ...
Toward high sequence coverage of proteins in human breast cancer cells using on-line monolith-based HPLC-ESI-TOF MS compared to CE MS
(WILEY-VCH Verlag, 2006-06)
A method is developed toward high sequence coverage of proteins isolated from human breast cancer MCF10 cell lines using a 2-D liquid separations. Monolithic-capillary columns prepared by copolymerizing styrene with ...
Diffusion of Alexa Fluor 488-Conjugated Dendrimers in Rat Aortic Tissue
(Blackwell Publishing Inc, 2006-11)
In this study, the distribution of labeled dendrimers in native and aneurysmal rat aortic tissue was examined. Adult male rats underwent infrarenal aorta perfusion with generation 5 (G5) acetylated Alexa Fluor 488-conjugated ...
Somatic mutations affect key pathways in lung adenocarcinoma
(Nature Publishing Group, 2008-10-23)
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well- classified primary tumours. Here we report the results of a collaborative study to discover somatic ...