Now showing items 1-10 of 12
eClinic: increasing use of telehealth as a risk reduction strategy during the covid-19 pandemic
(BMJ Journals, 2020)
Prior to the covid-19 pandemic, telehealth was already being rapidly adopted nationally by healthcare systems. During the covid-19 pandemic, increased use of telehealth may be considered as a risk reduction strategy. ...
Not Dying Alone — Modern Compassionate Care in the Covid-19 Pandemic
(Massachusetts Medical Society, 2020-06)
Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
(Springer Science and Business Media LLC, 2021-08-06)
Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive but provide the most effective improvements in obesity and Type 2 diabetes. We hypothesized a potential role for the gut hormone Fibroblast-Growth ...
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity
(Springer Nature, 2021-04-01)
Targeting the p53–MDM2 pathway to reactivate tumor p53 is a chemotherapeutic approach. However, the involvement of this pathway in CD8+ T cell-mediated antitumor immunity is unknown. Here, we report that mice with MDM2 ...
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
(Elsevier, 2021-01-01)
Tumor cell intrinsic ferroptosis-initiating mechanisms are unknown. Here, we discover that T cell-derived interferon (IFN)γ in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mode ...
Loss of optineurin drives cancer immune evasion via palmitoylation-dependent ifngr1 lysosomal sorting and degradation
(American Association for Cancer Research (AACR), 2021-07-01)
Mutations in IFN and MHC signaling genes endow immunotherapy resistance. Patients with colorectal cancer infrequently exhibit IFN and MHC signaling gene mutations and are generally resistant to immunotherapy. In exploring ...
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
(Springer Nature, 2020-09-10)
Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours1–4, but the cause of this link is unknown. Here we show that tumour cells disrupt methionine metabolism in CD8+ T cells, thereby lowering ...
Crotonylation at serine 46 impairs p53 activity
(Elsevier, 2020-04-09)
Post-translational modifications (PTMs) play pivotal roles in controlling the stability and activity of the tumor suppressor p53 in response to distinct stressors. Here we report an unexpected finding of a short chain fatty ...