Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus
dc.contributor.author | Sanchez, Elena | en_US |
dc.contributor.author | Webb, Ryan D. | en_US |
dc.contributor.author | Rasmussen, Astrid | en_US |
dc.contributor.author | Kelly, Jennifer A. | en_US |
dc.contributor.author | Riba, Laura | en_US |
dc.contributor.author | Kaufman, Kenneth M. | en_US |
dc.contributor.author | Garcia-de la Torre, Ignacio | en_US |
dc.contributor.author | Moctezuma, Jose F. | en_US |
dc.contributor.author | Maradiaga-Ceceña, Marco A. | en_US |
dc.contributor.author | Cardiel-Rios, Mario H. | en_US |
dc.contributor.author | Acevedo, Eduardo | en_US |
dc.contributor.author | Cucho-Venegas, Mariano | en_US |
dc.contributor.author | Garcia, Mercedes A. | en_US |
dc.contributor.author | Gamron, Susana | en_US |
dc.contributor.author | Pons-Estel, Bernardo A. | en_US |
dc.contributor.author | Vasconcelos, Carlos | en_US |
dc.contributor.author | Martin, Javier | en_US |
dc.contributor.author | Tusié-Luna, Teresa | en_US |
dc.contributor.author | Harley, John B. | en_US |
dc.contributor.author | Richardson, Bruce C. | en_US |
dc.contributor.author | Sawalha, Amr H. | en_US |
dc.contributor.author | Alarcón-Riquelme, Marta E. | en_US |
dc.date.accessioned | 2011-01-04T16:22:33Z | |
dc.date.available | 2011-03-01T16:26:42Z | en_US |
dc.date.issued | 2010-12 | en_US |
dc.identifier.citation | Sanchez, Elena; Webb, Ryan D.; Rasmussen, Astrid; Kelly, Jennifer A.; Riba, Laura; Kaufman, Kenneth M.; Garcia-de la Torre, Ignacio; Moctezuma, Jose F.; Maradiaga-CeceÑa, Marco A.; Cardiel-Rios, Mario H.; Acevedo, Eduardo; Cucho-Venegas, Mariano; Garcia, Mercedes A.; Gamron, Susana; Pons-Estel, Bernardo A.; Vasconcelos, Carlos; Martin, Javier; TusiÉ-Luna, Teresa; Harley, John B.; Richardson, Bruce; Sawalha, Amr H.; AlarcÓn-Riquelme, Marta E. (2010). "Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus." Arthritis & Rheumatism 62(12): 3722-3729. <http://hdl.handle.net/2027.42/78480> | en_US |
dc.identifier.issn | 0004-3591 | en_US |
dc.identifier.issn | 1529-0131 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78480 | |
dc.description.abstract | Objective To assess whether genetically determined Amerindian ancestry predicts increased presence of risk alleles of known susceptibility genes for systemic lupus erythematosus (SLE). Methods Single-nucleotide polymorphisms (SNPs) within 16 confirmed genetic susceptibility loci for SLE were genotyped in a set of 804 Mestizo lupus patients and 667 Mestizo healthy controls. In addition, 347 admixture informative markers were genotyped. Individual ancestry proportions were determined using STRUCTURE. Association analysis was performed using PLINK, and correlation between ancestry and the presence of risk alleles was analyzed using linear regression. Results A meta-analysis of the genetic association of the 16 SNPs across populations showed that TNFSF4 , STAT4 , ITGAM , and IRF5 were associated with lupus in a Hispanic Mestizo cohort enriched for European and Amerindian ancestry. In addition, 2 SNPs within the major histocompatibility complex region, previously shown to be associated in a genome-wide association study in Europeans, were also associated in Mestizos. Using linear regression, we predicted an average increase of 2.34 risk alleles when comparing an SLE patient with 100% Amerindian ancestry versus an SLE patient with 0% Amerindian ancestry ( P < 0.0001). SLE patients with 43% more Amerindian ancestry were predicted to carry 1 additional risk allele. Conclusion Our results demonstrate that Amerindian ancestry is associated with an increased number of risk alleles for SLE. | en_US |
dc.format.extent | 216889 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.title | Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan and VAMC, Ann Arbor | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation, Oklahoma City | en_US |
dc.contributor.affiliationother | University of Oklahoma Health Sciences Center, Oklahoma City | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation, Oklahoma City | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation, Oklahoma City | en_US |
dc.contributor.affiliationother | Instituto de Investigaciones BiomÉdicas de la Universidad Nacional AutÓnoma de MÉxico, and Instituto Nacional de Ciencias MÉdicas y NutriciÓn Salvador ZubirÁn, Mexico City, Mexico | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, and VAMC, Oklahoma City | en_US |
dc.contributor.affiliationother | Hospital General de Occidente, Zapopan, Mexico | en_US |
dc.contributor.affiliationother | Hospital General de MÉxico, Mexico City, Mexico | en_US |
dc.contributor.affiliationother | Hospital General de CuliacÁn, Culiacan, Mexico | en_US |
dc.contributor.affiliationother | Hospital General Dr. Miguel Silva, Morelia, Mexico | en_US |
dc.contributor.affiliationother | Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru | en_US |
dc.contributor.affiliationother | Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru | en_US |
dc.contributor.affiliationother | Hospital Interzonal General de Agudos “General San MartÍn,” La Plata, Argentina | en_US |
dc.contributor.affiliationother | Hospital Nacional de ClÍnicas, Universidad Nacional de CÓrdoba, Cordoba, Argentina | en_US |
dc.contributor.affiliationother | Sanatorio Parque, Rosario, Argentina | en_US |
dc.contributor.affiliationother | Hospital Santo Antonio, Unidade Multidisciplinar em InvestigaÇÃo BiomÉdica/Instituto de CiÊncias BiomÉdicas de Abel Salazar, Porto, Portugal ; Dr. Vasconcelos has received consulting fees, speaking fees, and/or honoraria from Merck, Sharp, and Dohme and Roche (less than $10,000 each). | en_US |
dc.contributor.affiliationother | Instituto de Biomedicina y ParasitologÍa LÓpez-Neyra, Consejo Superior de Investigaciones CientÍficas, Granada, Spain | en_US |
dc.contributor.affiliationother | Instituto de Investigaciones BiomÉdicas de la Universidad Nacional AutÓnoma de MÉxico, and Instituto Nacional de Ciencias MÉdicas y NutriciÓn Salvador ZubirÁn, Mexico City, Mexico | en_US |
dc.contributor.affiliationother | Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio ; Dr. Harley has received consulting fees, speaking fees, and/or honoraria from Biorad Labs, Immunovision, and IVAX Diagnostics (more than $10,000 each) and owns stock in IVAX Diagnostics. | en_US |
dc.contributor.affiliationother | Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, and VAMC, Oklahoma City ; Drs. Sawalha and AlarcÓn-Riquelme contributed equally to this work. | en_US |
dc.contributor.affiliationother | Pfizer–Universidad de Granada–Junta de AndalucÍa, Granada, Spain and Oklahoma Medical Research Foundation, Oklahoma City ; Oklahoma Medical Research Foundation, 825 NE 13th Street, MS #24, Oklahoma City, OK 73104 | en_US |
dc.identifier.pmid | 20848568 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78480/1/27753_ftp.pdf | |
dc.identifier.doi | 10.1002/art.27753 | en_US |
dc.identifier.source | Arthritis & Rheumatism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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