Methylene Blue-Conjugated Hydrogel Nanoparticles and Tumor-Cell Targeted Photodynamic Therapy
dc.contributor.author | Hah, Hoe Jin | en_US |
dc.contributor.author | Kim, Gwangseong | en_US |
dc.contributor.author | Lee, Yong-Eun Koo | en_US |
dc.contributor.author | Orringer, Daniel A. | en_US |
dc.contributor.author | Sagher, Oren | en_US |
dc.contributor.author | Philbert, Martin A. | en_US |
dc.contributor.author | Kopelman, Raoul | en_US |
dc.date.accessioned | 2011-01-04T16:22:47Z | |
dc.date.available | 2012-02-21T18:47:00Z | en_US |
dc.date.issued | 2011-01-10 | en_US |
dc.identifier.citation | Hah, Hoe Jin; Kim, Gwangseong; Lee, Yong-Eun Koo; Orringer, Daniel A.; Sagher, Oren; Philbert, Martin A.; Kopelman, Raoul (2011). "Methylene Blue-Conjugated Hydrogel Nanoparticles and Tumor-Cell Targeted Photodynamic Therapy." Macromolecular Bioscience 11(1): 90-99. <http://hdl.handle.net/2027.42/78482> | en_US |
dc.identifier.issn | 1616-5187 | en_US |
dc.identifier.issn | 1616-5195 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78482 | |
dc.description.abstract | Methylene blue-conjugated polyacrylamide nanoparticles are prepared through a microemulsion polymerization, after conjugation of the dye with a monomer. The nanoparticles have a 50–60 nm diameter in solution. This conjugation method enables a large increase in loading of methylene blue per nanoparticle and also minimizes dye leaching out of the nanoparticle. Furthermore, the dye content can be controlled by variation of the dye amount, enabling a more refined control of the singlet oxygen production ability. The nanoparticles are coated with F3 peptides, which give specific targeting to selected tumor cells, 9L, MDA-MB-435, and F98, in vitro. In addition, MTT assays reveal that the nanoparticles have no dark toxicity but excellent PDT efficacy increasing with the nanoparticle dose and irradiation time. | en_US |
dc.format.extent | 285647 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Biochemistry and Biotechnology | en_US |
dc.title | Methylene Blue-Conjugated Hydrogel Nanoparticles and Tumor-Cell Targeted Photodynamic Therapy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, Michigan 48109, USA ; Department of Chemistry, University of Michigan, 930 N. University, Ann Arbor, Michigan 48109, USA, Fax: (+1) 734 936 2778. | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Department of Neurosurgery, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Department of Environmental Health Sciences, 1415 Washington Heights, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 20976722 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78482/1/mabi_201000231_sm_supplfigs.pdf | |
dc.identifier.doi | 10.1002/mabi.201000231 | en_US |
dc.identifier.source | Macromolecular Bioscience | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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