Predictors of insufficient sweat production during confirmatory testing for cystic fibrosis
dc.contributor.author | Kleyn, Mary | en_US |
dc.contributor.author | Korzeniewski, Steven J. | en_US |
dc.contributor.author | Grigorescu, Violanda | en_US |
dc.contributor.author | Young, William I. | en_US |
dc.contributor.author | Homnick, Douglas | en_US |
dc.contributor.author | Goldstein-Filbrun, Amy | en_US |
dc.contributor.author | Schuen, John | en_US |
dc.contributor.author | Nasr, Samya Z. | en_US |
dc.date.accessioned | 2011-01-04T16:23:06Z | |
dc.date.available | 2012-02-21T18:47:00Z | en_US |
dc.date.issued | 2011-01 | en_US |
dc.identifier.citation | Kleyn, Mary; Korzeniewski, Steven; Grigorescu, Violanda; Young, William; Homnick, Douglas; Goldstein-Filbrun, Amy; Schuen, John; Nasr, Samya (2011). "Predictors of insufficient sweat production during confirmatory testing for cystic fibrosis." Pediatric Pulmonology 46(1): 23-30. <http://hdl.handle.net/2027.42/78485> | en_US |
dc.identifier.issn | 8755-6863 | en_US |
dc.identifier.issn | 1099-0496 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78485 | |
dc.description.abstract | Michigan's Newborn Screening (NBS) Program began statewide screening for cystic fibrosis (CF) in October 2007. Confirmatory sweat testing is performed in infants having initial immunoreactive trypsinogen concentrations ≥99.8th percentile or ≥96th percentile and at least one CF mutation identified by DNA analysis. Some infants fail to produce a sufficient quantity of sweat (QNS—quantity not sufficient) to test for CF, meaning disease confirmation is delayed and sweat testing is later repeated. In this study, we evaluate predictors of QNS results. Information from the linked birth certificates and NBS diagnostic confirmation data were used. The study population was resident infants born in Michigan in 2008 who underwent a sweat test. Bivariate analyses revealed that preterm birth, low birth weight, CF care center, and race were significantly associated with QNS sweat testing results. Adjusted analyses indicated that preterm infants were 2.4 times more likely to have QNS results (95% CI 0.9, 6.4). When age at time of test, accounting for gestational age (gestational age at delivery plus postdelivery age of life = corrected age), was used in the multivariable model, infants <39 weeks were 7.4 times more likely to have QNS results (95% CI 2.5, 21.8). Waiting to sweat test until an infant is aged 39 weeks or more (corrected age) would likely reduce the rate of QNS results, thereby reducing the burden of repeat sweat testing on families and healthcare providers. Further research is necessary to understand the impact of potential delays in diagnosis/treatment relative to postponing sweat testing. Pediatr Pulmonol. 2011; 46:23–30. © 2010 Wiley-Liss, Inc. | en_US |
dc.format.extent | 90963 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Miscellaneous Medical | en_US |
dc.title | Predictors of insufficient sweat production during confirmatory testing for cystic fibrosis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Cystic Fibrosis Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan Cystic Fibrosis Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Michigan Department of Community Health, Lansing, Michigan ; 201 Townsend Street, P.O. Box 30195, Lansing, MI 48909. | en_US |
dc.contributor.affiliationother | Michigan Department of Community Health, Lansing, Michigan | en_US |
dc.contributor.affiliationother | Michigan Department of Community Health, Lansing, Michigan | en_US |
dc.contributor.affiliationother | Michigan Department of Community Health, Lansing, Michigan | en_US |
dc.contributor.affiliationother | Kalamazoo Center for Medical Studies Cystic Fibrosis Center, Kalamazoo, Michigan | en_US |
dc.contributor.affiliationother | DeVos Cystic Fibrosis Care Center, Grand Rapids, Michigan | en_US |
dc.identifier.pmid | 20812243 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78485/1/21318_ftp.pdf | |
dc.identifier.doi | 10.1002/ppul.21318 | en_US |
dc.identifier.source | Pediatric Pulmonology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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