The severity of osteogenesis imperfecta: A comparison to the relative free energy differences of collagen model peptides
dc.contributor.author | Lee, Kyung-Hoon | en_US |
dc.contributor.author | Kuczera, Krzysztof | en_US |
dc.contributor.author | Banaszak Holl, Mark M. | en_US |
dc.date.accessioned | 2011-01-04T16:25:05Z | |
dc.date.available | 2012-02-21T18:47:02Z | en_US |
dc.date.issued | 2011-03 | en_US |
dc.identifier.citation | Lee, Kyung-Hoon; Kuczera, Krzysztof; Banaszak Holl, Mark M. (2011). "The severity of osteogenesis imperfecta: A comparison to the relative free energy differences of collagen model peptides." Biopolymers 95(3): 182-193. <http://hdl.handle.net/2027.42/78503> | en_US |
dc.identifier.issn | 0006-3525 | en_US |
dc.identifier.issn | 1097-0282 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78503 | |
dc.description.abstract | Molecular dynamics simulations were carried out to calculate free energy differences between the folded and unfolded states of wild type and mutant collagen model peptides. The calculated stability of the collagen models was compared with the severity of osteogenesis imperfecta. Free energy differences of Gly → Xaa (Xaa: Ser, Cys, Glu, and Asp) mutations between the wild type and the mutants at position 15 of the model peptide were 3.8, 4.2, 5.6, and 8.8 kcal/mol, respectively. The corresponding free energy differences of a second Gly mutation at the same position in different chains were, on average, 1.3, 1.5, 2.9, and 5.4 kcal/mol, respectively. Free energy simulations were also performed to estimate the relative stability between an oxidized form and a reduced form of the mutants containing two Cys residues, which indicated that the mutant of the collagen-like peptide containing an intramolecular disulfide bond was more stable than the mutant containing one Cys residue but less stable than the wild type. The calculated free energy differences between an oxidized and a reduced form of the mutants containing two Cys residues are 0.8 and 2.6 kcal/mol for the disulfide bonds between Chains A and B and between Chains A and C, respectively. © 2010 Wiley Periodicals, Inc. Biopolymers 95: 182–193, 2011. | en_US |
dc.format.extent | 334370 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | The severity of osteogenesis imperfecta: A comparison to the relative free energy differences of collagen model peptides | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute in Medicine and Biological Sciences, and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Michigan Nanotechnology Institute in Medicine and Biological Sciences, and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 ; Michigan Nanotechnology Institute in Medicine and Biological Sciences, and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationother | Department of Chemistry and Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045 | en_US |
dc.identifier.pmid | 20945334 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78503/1/21552_ftp.pdf | |
dc.identifier.doi | 10.1002/bip.21552 | en_US |
dc.identifier.source | Biopolymers | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.