Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA)
dc.contributor.author | Nettleton, Jennifer A. | |
dc.contributor.author | Diez Roux, Ana V. | |
dc.contributor.author | Jenny, Nancy S. | |
dc.contributor.author | Fitzpatrick, AL | |
dc.contributor.author | Jacobs, David R., Jr. | |
dc.date.accessioned | 2011-01-05T17:13:07Z | |
dc.date.available | 2011-01-05T17:13:07Z | |
dc.date.issued | 2008-11 | |
dc.identifier.citation | Am J Clin Nutr. 2008 Nov;88(5):1405-12. <http://hdl.handle.net/2027.42/78527> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78527 | |
dc.description.abstract | BACKGROUND: Telomere length reflects biological aging and may be influenced by environmental factors, including those that affect inflammatory processes. OBJECTIVE: With data from 840 white, black, and Hispanic adults from the Multi-Ethnic Study of Atherosclerosis, we studied cross-sectional associations between telomere length and dietary patterns and foods and beverages that were associated with markers of inflammation. DESIGN: Leukocyte telomere length was measured by quantitative polymerase chain reaction. Length was calculated as the amount of telomeric DNA (T) divided by the amount of a single-copy control DNA (S) (T/S ratio). Intake of whole grains, fruit and vegetables, low-fat dairy, nuts or seeds, nonfried fish, coffee, refined grains, fried foods, red meat, processed meat, and sugar-sweetened soda were computed with responses to a 120-item food-frequency questionnaire completed at baseline. Scores on 2 previously defined empirical dietary patterns were also computed for each participant. RESULTS: After adjustment for age, other demographics, lifestyle factors, and intakes of other foods or beverages, only processed meat intake was associated with telomere length. For every 1 serving/d greater intake of processed meat, the T/S ratio was 0.07 smaller (beta +/- SE: -0.07 +/- 0.03, P = 0.006). Categorical analysis showed that participants consuming >or=1 serving of processed meat each week had 0.017 smaller T/S ratios than did nonconsumers. Other foods or beverages and the 2 dietary patterns were not associated with telomere length. CONCLUSIONS: Processed meat intake showed an expected inverse association with telomere length, but other diet features did not show their expected associations. | en_US |
dc.format.extent | 123480 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.title | Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA) | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.contributor.affiliationum | Epidemiology, Department of | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78527/1/NettletonDiezRoux2008_AmJClinNutr.pdf | |
dc.owningcollname | Epidemiology, Department of (SPH) |
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