Now showing items 1-10 of 16
Actin polymerization in cellular oxidant injury
(Elsevier, 1991-08-01)
Microfilaments undergo an ATP-dependent disruption into shortened bundles following cellular exposure to oxidants. This phenomenon does not require a net change in the amount of polymerized actin. However, increased amounts ...
Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-01)
Current treatment protocol for postoperative pain is to infuse anesthetic solution around nerves or into the epidural space. This clinical practice is beset by the short duration of the anesthetic effect unless the infusion ...
Activation by anti-CD3 of tumor-draining lymph node cells for specific adoptive immunotherapy
(Elsevier, 1991-05)
Lymph nodes draining progressive tumors contain tumor-sensitized but not functional preeffector T lymphocytes. These cells can acquire antitumor reactivity after stimulation with tumor cells and interleukin-2 (IL-2). We ...
Gene gun application in the generation of effector T cells for adoptive immunotherapy
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-01)
We utilized the gene gun to transfect subcutaneous D5 melanoma and MT-901 mammary carcinoma tumors in situ with a granulocyte/macrophage-colony-stimulating factor (GM-CSF) plasmid complexed to gold particles. There was ...
Distinct immunologic specificity of tumor regression mediated by effector cells isolated from immunized and tumor-bearing mice
(Elsevier, 1989-05)
Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumorbearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells by immunization of ...
CTLA-4 blockade augments human T lymphocyte-mediated suppression of lung tumor xenografts in SCID mice
(Springer-Verlag, 2005-10)
Previous studies by others using transplantable murine tumor models have demonstrated that the administration of antibodies that block CTLA-4 interaction with B7 can provoke the elimination of established tumors, and that ...
Scintigraphy of incidentally discovered bilateral adrenal masses
(Springer-Verlag, 1995-04)
The purpose of this study was to determine the patterns of iodine-131 6β-iodomethylnorcholesterol (NP-59) imaging and the correlation with computed tomography (CT)-guided adrenal biopsy and follow-up in patients with ...
Injectable microparticle–gel system for prolonged and localized lidocaine release. II. in vivo anesthetic effects
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-01)
Current treatment protocols for postoperative pain are beset by either the short duration of the anesthetic effect or requirement of hospitalization of the patients. We reported herein a novel treatment by applying to the ...
Effector phenotype and immunologic specificity of T cell-mediated adoptive therapy for a murine tumor that lacks intrinsic immunogenicity
(Elsevier, 1990-08)
The MCA 102 sarcoma has been defined by a variety of immunologic studies as a tumor lacking intrinsic immunogenicity. Nevertheless, we have recently demonstrated the feasibility of generating therapeutically effective ...
Inhibition of organic anion transport in endothelial cells by hydrogen peroxide
(Elsevier, 1992-11-01)
ATP loss is a prominent feature of cellular injury induced by oxidants or ischemia. How reduction of cellular ATP levels contributes to lethal injury is still poorly understood. In this study we examined the ability of ...