Now showing items 1-6 of 6
Actin polymerization in cellular oxidant injury
(Elsevier, 1991-08-01)
Microfilaments undergo an ATP-dependent disruption into shortened bundles following cellular exposure to oxidants. This phenomenon does not require a net change in the amount of polymerized actin. However, increased amounts ...
Activation by anti-CD3 of tumor-draining lymph node cells for specific adoptive immunotherapy
(Elsevier, 1991-05)
Lymph nodes draining progressive tumors contain tumor-sensitized but not functional preeffector T lymphocytes. These cells can acquire antitumor reactivity after stimulation with tumor cells and interleukin-2 (IL-2). We ...
Distinct immunologic specificity of tumor regression mediated by effector cells isolated from immunized and tumor-bearing mice
(Elsevier, 1989-05)
Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumorbearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells by immunization of ...
Effector phenotype and immunologic specificity of T cell-mediated adoptive therapy for a murine tumor that lacks intrinsic immunogenicity
(Elsevier, 1990-08)
The MCA 102 sarcoma has been defined by a variety of immunologic studies as a tumor lacking intrinsic immunogenicity. Nevertheless, we have recently demonstrated the feasibility of generating therapeutically effective ...
Inhibition of organic anion transport in endothelial cells by hydrogen peroxide
(Elsevier, 1992-11-01)
ATP loss is a prominent feature of cellular injury induced by oxidants or ischemia. How reduction of cellular ATP levels contributes to lethal injury is still poorly understood. In this study we examined the ability of ...
Galanin inhibits rat pancreatic amylase release via cholinergic suppression
(Elsevier, 1992)
The effects of galanin on pancreatic exocrine function were examined using rat pancreatic tissues. In anesthetized rats, galanin (40 [mu]g/kg/h) decreased amylase secretion stimulated by 2-deoxy glucose (5.8 +/- 0.1 vs. ...