Now showing items 1-10 of 12
Current Status and Future Opportunities for Controlling Acromegaly
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-09)
Growth-hormone (GH) secreting adenomas, including acromegaly, account for approximately one-sixth of all pituitary adenomas and are associated with mortality rates at least twice that of the general population. The ultimate ...
Surgical reversal of prolonged blindness from a metastatic neuroblastoma
(Springer-Verlag, 2005-07)
Reports of tumor-related anterior visual pathway blindness that have resolved after surgical decompression are rare. The longest reported duration of tumor-related blindness completely reversed by optic nerve decompression ...
Intramedullary Spinal Tumors of Disordered Embryogenesis
(Kluwer Academic Publishers; Springer Science+Business Media, 2000-05)
Abnormal spinal embryogenesis is quite commonplace. While greater than 90 percent of these errors of embryogenesis leads to occult spinal dysraphism with minimal neurologic or orthopedic sequelae, there is a significant ...
Rapid Re-expansion of a Macroprolactinoma After Early Discontinuation of Bromocriptine
(Kluwer Academic Publishers; Springer Science+Business Media, 2000-11)
Prolactin (PRL)-secreting pituitary adenomas are the most common functioning pituitary tumors. Medical treatment with dopamine agonists is the therapy of choice for macroprolactinomas (≥10 mm). Withdrawal of bromocriptine ...
Pergolide As Primary Therapy for Macroprolactinomas
(Kluwer Academic Publishers; Springer Science+Business Media, 2000-12)
The objective of this study is to determine whether pergolide therapy is an effective modality for the de novo treatment of patients with macroprolactinomas. Twenty-two consecutive patients with macroprolactinomas were ...
Medical Management of Growth Hormone-Secreting Pituitary Adenomas
(Kluwer Academic Publishers; Springer Science+Business Media, 2002-06)
The primary treatment of acromegaly remains transsphenoidal adenomectomy, yet the tissue overgrowth of acromegaly often progresses following surgery, and responds to radiotherapy only after significant delay. Persistently ...
Effect of dietary vitamin A or N-acetylcysteine on ethylnitrosourea-induced rat gliomas
(Kluwer Academic Publishers; Springer Science+Business Media, 1998-10)
It is our hypothesis that low grade gliomas are the glial counterparts of other precancerous lesions such as colon polyps and, therefore, suitable targets for chemoprevention. Steps in the molecular progression of gliomas ...
Magnetic Resonance Imaging of Ethyl-nitrosourea-induced Rat Gliomas: A Model for Experimental Therapeutics of Low-grade Gliomas
(Kluwer Academic Publishers; Springer Science+Business Media, 2001-07)
Human low-grade gliomas represent a population of brain tumors that remain a therapeutic challenge. Preclinical evaluation of agents, to test their preventive or therapeutic efficacy in these tumors, requires the use of ...
Growth Hormone (GH) Secretion in Primary Adrenal Insufficiency: Effects of Cortisol Withdrawal and Patterned Replacement on GH Pulsatility and Circadian Rhythmicity
(Kluwer Academic Publishers; Springer Science+Business Media, 2000-11)
We studied the effects of cortisol withdrawal and patterned replacement upon spontaneous GH secretion and circadian rhythmicity in 7 patients with Addison's disease. Hydrocortisone was administered in physiological daily ...
Somatotropinoma Infarction During Octreotide Therapy Leading to Bilateral Cavernous Sinus Syndrome
(Kluwer Academic Publishers; Springer Science+Business Media, 2000-11)
The cyclic somatostatin analog, octreotide, forms the mainstay of medical treatment for acromegaly. In addition to lowering circulating growth hormone levels and shrinking tumor size, octreotide may provide symptomatic ...