Now showing items 1-9 of 9
Further localization of a gene for paroxysmal dystonic choreoathetosis to a 5-cM region on chromosome 2q34
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-01)
Paroxysmal dystonic choreoathetosis (PDC) is a rare neurological disorder characterized by episodes of involuntary movement, involving the extremities and face, which may occur spontaneously or be precipitated by caffeine, ...
Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
(Springer-Verlag, 2006-04)
Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have suggested similar effects and correlated motor and cognitive ...
Nicotine may relieve symptoms of Parkinson's disease
(Springer-Verlag, 1994-09)
Two elderly patients with Parkinson's disease were treated with nicotine gum and patch. Reliable changes in symptomatology were noted, using a single-subject, placebo-control reversal design. Improvement was associated ...
Autoradiographic quantification of muscarinic cholinergic synaptic markers in bat, shrew, and rat brain
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-05)
We employed radioligand binding autoradiography to determine the distributions of pre- and postsynaptic cholinergic radioligand binding sites in the brains of two species of bat, one species of shrew, and the rat. High ...
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders
(Springer-Verlag, 2001-10)
Rationale: There exists a wide range of animal models and measures designed to assess anxiety or fearfulness. However, the relationship between these models and clinical anxiety symptoms and syndromes is unclear. The ...
The importance of age effects on performance in the assessment of clinical trials
(Elsevier, 1973-11)
Forty young adult normal subjects, 10 Parkinson's disease patients and their 10 matched normal subjects, and 10 multiple sclerosis patients and their 10 matched normal subjects were evaluated in the Quantitative Examination ...
A qualitative and quantitative evaluation of amantadine in the treatment of Parkinson's disease
(Elsevier, 1972-03)
A double-blind crossover trial of amantadine vs. placebo was carried out involving 42 patients with Parkinson's disease: 64 per cent of the patients on amantadine experienced subjective improvement compared to 21 per cent ...
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
(Springer-Verlag, 2006-05)
The effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which ...
Quantitative in vivo receptor binding IV: Detection of muscarinic receptor down-regulation by equilibrium and by tracer kinetic methods
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1991-09)
Newly-developed methods for estimation of in vivo binding to neurotransmitter receptors should enable the detection and quantification of physiologic or pathologic changes in receptor numbers. In the present study, both ...