Now showing items 1-10 of 38
Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease
(Wiley Subscription Services, Inc., A Wiley Company, 2004-06)
We used positron emission tomography (PET) with (+)-[ 11 C]dihydrotetrabenazine ([+]-[ 11 C]DTBZ) to examine striatal monoaminergic presynaptic terminal density in 20 patients with dementia with Lewy bodies (DLB), 25 with ...
Facial EMG activity levels predict treatment outcome in depression
(Elsevier, 1984-12)
Higher electromyographic (EMG) activity levels of corrugator and zygomatic face muscles have been reported to be pretreatment predictors of better clinical outcome in depressed patients. We tested this possibility in 29 ...
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
(Wiley Subscription Services, Inc., A Wiley Company, 1997-07)
This study investigated cerebral glucose metabolism in very early Alzheimer's disease, before a clinical diagnosis of probable Alzheimer's disease is possible, using [ 18 F]fluorodeoxyglucose positron emission tomography. ...
Thalamic, brainstem, and cerebellar glucose metabolism in the hemiplegic monkey
(Wiley Subscription Services, Inc., A Wiley Company, 1988-12)
Unilateral ablation of cerebral cortical areas 4 and 6 of Brodmann in the macaque monkey results in a contralateral hemiplegia that resolves partially with time. During the phase of dense hemiplegia, local cerebral metabolic ...
Anxiety and cerebral cortical metabolism in normal persons
(Elsevier, 1990-04)
The State-Trait Anxiety Inventory (STAI) was administered to 43 normal volunteers immediately before and after a positron emission tomography (PET) procedure with [18F]-2-fluoro-2-deoxy-D-glucose (18F-FDG). High traitanxious ...
In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses
(Wiley Subscription Services, Inc., A Wiley Company, 2006-01)
Objective We tested the premise that cholinesterase inhibitor therapy should target butyrylcholinesterase (BuChE) in Alzheimer's disease (AD), not acetylcholinesterase (AChE) alone, because both enzymes hydrolyze ...
Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
(Springer-Verlag, 2006-04)
Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have suggested similar effects and correlated motor and cognitive ...
Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex
(John Wiley & Sons, Inc., 2000-09)
Based on surrogate assays of peripheral red blood cells, reports state that widely prescribed doses of donepezil hydrochloride provide nearly complete inhibition of cerebral cortical acetylcholinesterase activity in the ...