Now showing items 1-10 of 11
A sequential double-label autoradiographic method that quantifies altered rates of regional glucose metabolism
(Elsevier, 1985-12-30)
An autoradiographic sequential double-label variant of the deoxyglucose method for measurement of local glucose utilization has been developed. This technique takes advantage of the short half-life of the positron emitter, ...
Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element
(Wiley Subscription Services, Inc., A Wiley Company, 2009-08-15)
A classic morphogen, bone morphogenetic protein 2 (BMP2) regulates the differentiation of pluripotent mesenchymal cells. High BMP2 levels promote osteogenesis or chondrogenesis and low levels promote adipogenesis. BMP2 ...
Further localization of a gene for paroxysmal dystonic choreoathetosis to a 5-cM region on chromosome 2q34
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-01)
Paroxysmal dystonic choreoathetosis (PDC) is a rare neurological disorder characterized by episodes of involuntary movement, involving the extremities and face, which may occur spontaneously or be precipitated by caffeine, ...
A densitometer for quantitative autoradiography
(Elsevier, 1983-11)
A low cost spot densitometer system is described. This system is useful for quantitative autoradiography of local cerebral glucose utilization, blood flow, receptor binding and other applications requiring densitometry on ...
Vesicular neurotransmitter transporters in Huntington's disease: Initial observations and comparison with traditional synaptic markers
(John Wiley & Sons, Inc., 2001-09-15)
Markers of identified neuronal populations have previously suggested selective degeneration of projection neurons in Huntington's disease (HD) striatum. Interpretations are, however, limited by effects of compensatory ...
Transient 23–30 Hz oscillations in mouse hippocampus during exploration of novel environments
(Wiley Subscription Services, Inc., A Wiley Company, 2008-05)
The hippocampus is a key brain structure for the encoding of new experiences and environments. Hippocampal activity shows distinct oscillatory patterns, but the relationships between oscillations and memory are not well ...
Assessment of muscarinic receptor concentrations in aging and Alzheimer disease with [ 11 C]NMPB and PET
(John Wiley & Sons, Inc., 2001-03-15)
Cerebral cholinergic deficits have been described in Alzheimer disease (AD) and as a result of normal aging. At the present time, there are very limited options for the quantification of cholinergic receptors with in vivo ...
Autoradiographic quantification of muscarinic cholinergic synaptic markers in bat, shrew, and rat brain
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1994-05)
We employed radioligand binding autoradiography to determine the distributions of pre- and postsynaptic cholinergic radioligand binding sites in the brains of two species of bat, one species of shrew, and the rat. High ...
Localization of muscarinic M3 receptor protein and M3 receptor binding in rat brain
(Elsevier, 1994-11)
A family of receptor subtypes, defined either by molecular (ml-m5) or pharmacological (M1-M4) analysis, mediates muscarinic cholinergic neurotransmission in brain. The distribution and functions of the m3 receptor protein ...
[ 18 F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses
(John Wiley & Sons, Inc., 1998-11)
Loss of cholinergic transmission in the cortex and hippocampus is a characteristic feature of Alzheimer's disease, and visualization of functional cholinergic synapses in the brain with PET could be a useful method for ...